慢性阻塞性肺疾病（COPD）和肌肉减少症对美国成年人全因死亡率和呼吸死亡率的影响：1999 - 2018年美国国家健康与营养检查调查（NHANES）

Impact of COPD and sarcopenia on all-cause and respiratory mortality in US adults: NHANES 1999-2018.

作者信息

Xu Jiao, Ma Yuehua, Zeng Qingyue, Mu Xingyu, Nie Hu, Li Shuangqing, Su Qiaoli, Fan Hong

机构信息

Department of General Practice Medical Center, West China Hospital, Sichuan University, No.37 Guoxue Lane, Wuhou District, Chengdu, Sichuan, China.

Emergency Department, West China Hospital, Sichuan University, No.37 Guoxue Lane, Wuhou District, Chengdu, Sichuan, China.

出版信息

BMC Pulm Med. 2025 May 9;25(1):223. doi: 10.1186/s12890-025-03675-0.

DOI:10.1186/s12890-025-03675-0

PMID:40346539

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12063412/

Abstract

BACKGROUND

Chronic Obstructive Pulmonary Disease (COPD) and sarcopenia (SAR) are major public health problems in aging societies, as they share common pathophysiological mechanisms and are associated with serious health consequences. We estimated the impact of COPD and SAR on all-cause and respiratory mortalities in the US adult population.

METHODS

The study analyzed data from the National Health and Nutrition Examination Surveys (NHANES), a representative sample of the US population. Participants aged 20 years or older who had reported whole-body dual X-ray absorptiometry data and data required for the diagnosis of COPD were included. Participants were divided into four groups based on the presence of COPD and SAR.

RESULTS

Compared to the COPD-/SAR - group, the COPD-/SAR+, COPD+/SAR-, and COPD+/SAR + groups all demonstrated increased all-cause mortality with Hazard Ratios (HRs) of 1.33 (95% CI 1.20-1.48), 1.51 (95% CI 1.21-1.88), and 1.87 (95% CI 1.32-2.66), respectively. In addition, both the COPD+/SAR - and COPD+/SAR + groups demonstrated increased respiratory mortality with HRs of 5.16 (95% CI 2.96-9.01), and 8.69 (95% CI 3.95-19.1) compared to the COPD-/SAR - group.

CONCLUSIONS

The coexistence of COPD and SAR additively increased the risk of all-cause and respiratory mortality. Individuals with one of these diseases may need to be treated more carefully to prevent the development of the other disease and thus reduce mortality.

摘要

背景

慢性阻塞性肺疾病（COPD）和肌少症（SAR）是老龄化社会中的主要公共卫生问题，因为它们具有共同的病理生理机制，且会导致严重的健康后果。我们评估了COPD和SAR对美国成年人群全因死亡率和呼吸死亡率的影响。

方法

该研究分析了来自美国国家健康与营养检查调查（NHANES）的数据，这是美国人口的代表性样本。纳入了年龄在20岁及以上且报告了全身双能X线吸收测定数据以及COPD诊断所需数据的参与者。参与者根据是否存在COPD和SAR分为四组。

结果

与COPD-/SAR-组相比，COPD-/SAR+组、COPD+/SAR-组和COPD+/SAR+组的全因死亡率均有所增加，风险比（HR）分别为1.33（95%CI 1.20-1.48）、1.51（95%CI 1.21-1.88）和1.87（95%CI 1.32-2.66）。此外，与COPD-/SAR-组相比，COPD+/SAR-组和COPD+/SAR+组的呼吸死亡率也有所增加，HR分别为5.16（95%CI 2.96-9.01）和8.69（95%CI 3.95-19.1）。