AIT Austrian Institute of Technology GmbH, Center for Health & Bioresources, Giefinggasse 4, 1210, Vienna, Austria.
AIT Austrian Institute of Technology GmbH, Center for Health & Bioresources, Giefinggasse 4, 1210, Vienna, Austria.
Biosens Bioelectron. 2022 Feb 1;197:113816. doi: 10.1016/j.bios.2021.113816. Epub 2021 Nov 18.
Single-mode organic solid-state lasers with direct emission into an optical waveguide are attractive candidates for cost-efficient coherent light sources employed in photonic lab-on-a-chip biosensors. Here, we present a combination of a dye-doped organic solid-state distributed feedback laser with a highly sensitive optical waveguide Mach-Zehnder interferometer on a silicon nitride photonic platform. This organic-hybrid laser allows for optical pumping with a laser diode in an alignment tolerant manner, which facilitates applications in point-of-care diagnostics. The sensitivity to bulk refractive index changes and the concentration dependent binding of streptavidin on a polyethyleneimine-biotin functionalized surface was studied to demonstrate the practicability of this cost-efficient coherent light source for optical waveguide biosensors.
单模有机固态激光器直接发射到光波导中，是在光子芯片生物传感器中使用的低成本相干光源的理想候选者。在这里，我们将掺染料的有机固态分布式反馈激光器与氮化硅光子平台上的高灵敏度光波导马赫-曾德尔干涉仪相结合。这种有机混合激光器可以在容忍对准的情况下用激光二极管进行光学泵浦，这为即时诊断应用提供了便利。我们研究了对体折射率变化的灵敏度以及聚乙二烯亚胺-生物素功能化表面上链霉亲和素的浓度依赖性结合，以证明这种低成本相干光源对于光波导生物传感器的实用性。
