[(9;11)(p21;q23)易位：关于急性未分化单核细胞白血病5a型中发现的2例新病例]
[(9;11) (p21;q23) translocation: apropos of 2 new cases seen in acute undifferentiated monoblastic AML5a leukemia].
作者信息
Laï J L, Jouet J P, Zandecki M, Savary J B, Fenaux P, Lepelley P, Nelken B, Bauters F, Deminatti M
机构信息
Service de Génétique, Faculté de Médecine, Lille, France.
出版信息
Nouv Rev Fr Hematol (1978). 1987;29(5):303-6.
In a cytogenetic study of 54 patients with acute monoblastic leukaemias (AML5) two had a (9;11) (p21;q23) translocation. In addition to the clone, with t(9;11), both patients had a second clone with t(9;11) and trisomy 8. These two patients were aged 23 and 35 years at diagnosis and were classified as M5a in the FAB formulation. A complete remission was achieved in each case, persisting after 19 and 18 months respectively (autograft for one patient). Whereas chromosome 11 anomalies are involved in 13% of all AML5 cases, t(9;11) is less frequently encountered (3.7% in our experience).
在一项对54例急性单核细胞白血病（AML5）患者的细胞遗传学研究中，有2例发生了（9；11）（p21；q23）易位。除了带有t（9；11）的克隆外，这两名患者都还有一个带有t（9；11）和8号染色体三体的第二个克隆。这两名患者诊断时年龄分别为23岁和35岁，在FAB分型中被归类为M5a。两例均实现了完全缓解，分别持续了19个月和18个月（其中1例患者进行了自体移植）。虽然11号染色体异常在所有AML5病例中占13%，但t（9；11）则较少见（根据我们的经验为3.7%）。
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