Department of Forensic Sciences, Oslo University Hospital, Oslo, Norway
Institute of Health and Society, Faculty of Medicine, University of Oslo, Oslo, Norway.
BMJ Open. 2021 Nov 23;11(11):e052428. doi: 10.1136/bmjopen-2021-052428.
In order to target the complex health needs of patients with multimorbidity using psychoactive substances, knowledge regarding the association between substance use and multimorbidity in an acute setting is needed.
Examine psychoactive substance use patterns among acute medically ill patients, and determine the association between multimorbidity and substance use, and psychological distress.
Cross-sectional study.
2874 acute medically ill patients admitted to a medical emergency department in Oslo, Norway.
Primary outcome: multimorbidity recorded by the presence of ≥2 International Classification of Diseases 10th revision-physical and/or mental health conditions per patient, extracted from medical records. Predictor variables: self-reported data on age, sex, occupational status, psychological distress (Hopkins Symptom Check List-5), alcohol use (Alcohol Use Disorder Identification Test-4) and results from blood samples on psychoactive medicinal and illicit drugs.
Of all patients, 57.2% had multimorbidity. Of these, 62.6% reported psychological distress, 85.5% consumed either alcohol, medicinal and/or illicit drugs and 64.4% combined alcohol with psychoactive medicinal drugs. Patients with risky alcohol use were more likely to have multimorbidity compared with patients with low-risk alcohol use (OR 1.53; 95% CI 1.05 to 2.24). Patients using psychoactive medicinal drugs were more likely to have multimorbidity compared with non-users (OR 1.34; 95% CI 1.07 to 1.67).
Multimorbidity was associated with psychoactive medicinal drug and risky alcohol use, and psychological distress. Substance use was widespread, with alcohol and psychoactive medicinal drugs most frequently combined. Monitoring substance use among multimorbid patients is necessary to develop tailored treatments, and reduce burden on the healthcare system.
为了针对患有多种合并症的患者的复杂健康需求使用精神活性物质，需要了解急性环境中物质使用与多种合并症之间的关系。
检查急性患病患者的精神活性物质使用模式，并确定多种合并症与物质使用和心理困扰之间的关系。
横断面研究。
2874 名在挪威奥斯陆的医疗急救部门就诊的急性患病患者。
主要结局：通过每位患者存在≥2 种国际疾病分类第 10 版-身体和/或心理健康状况来记录多种合并症，这些信息从病历中提取。预测变量：年龄、性别、职业状况、心理困扰（霍普金斯症状清单-5）、酒精使用（酒精使用障碍识别测试-4）和从血液样本中提取的精神活性药物和非法药物的自我报告数据。
所有患者中，57.2%患有多种合并症。其中，62.6%报告有心理困扰，85.5%患者饮酒、使用药物和/或非法药物，64.4%患者同时饮酒和使用精神活性药物。与低风险饮酒的患者相比，有风险的饮酒患者更有可能患有多种合并症（比值比 1.53；95%置信区间 1.05 至 2.24）。与非使用者相比，使用精神活性药物的患者更有可能患有多种合并症（比值比 1.34；95%置信区间 1.07 至 1.67）。
多种合并症与精神活性药物和风险酒精使用以及心理困扰有关。物质使用很普遍，酒精和精神活性药物最常同时使用。对患有多种合并症的患者进行物质使用监测是必要的，以便制定针对性的治疗方案，并减轻医疗系统的负担。
