Obstetrics and Gynaecology, Amsterdam UMC, Amsterdam, The Netherlands
Obstetrics and Gynaecology, Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands.
BMJ Open. 2021 Nov 23;11(11):e052664. doi: 10.1136/bmjopen-2021-052664.
Uterine fibroids can cause a variety of symptoms in women, from heavy menstrual bleeding and dysmenorrhea to bulk symptoms. The Uterine Fibroid Symptom and health-related Quality Of Life questionnaire (UFS-QOL) is a patient-reported outcome measure developed for assessing fibroid-related symptoms in a standardised way. Our aim was to translate and validate the UFS-QOL in Dutch.
Validation study.
Patients were recruited by a gynaecologist at the outpatient clinic.
Women with uterine fibroids.
The UFS-QOL was translated into Dutch (UFS-QOL NL) and validated through testing construct validity (comprising of structural validity and hypotheses testing), reliability, responsiveness and interpretability, assessing floor and ceiling effects and minimal important change. An option to answer 'not applicable' was added to the translated questionnaire.
191 women with uterine fibroids completed the UFS-QOL NL at baseline, after 2 weeks and after 3 months. The questionnaire retained the same factor structure after translation (Comparative Fit Index 0.94-0.95; Tucker-Lewis fit Index 0.93-0.95; Root Mean Square Error of Approximation 0.10-0.11) and correlations to other questionnaires (RAND 36, Hospital Anxiety and Depression Scale and Golombok Rust Inventory of Sexual Satisfaction) were generally moderate, as hypothesised (Pearson's r 0.3-0.7). We found a sufficient reliability with intraclass correlation coefficients of approximately 0.8-0.9 for all subscales. Responsiveness was sufficient when testing hypotheses comparing women who had surgery with those who did not. Cronbach's alpha was higher than 0.7 for all subscales, indicating sufficient internal consistency and there were no concerns about floor or ceiling effects. Minimal important change could not be calculated due to low correlation between the different subscales and the anchor question.
The results support the measurement properties of the Dutch UFS-QOL for assessing fibroid-related symptoms and health-related quality of life in Dutch women with uterine fibroids.
子宫肌瘤可导致女性出现多种症状，从月经过多和痛经到肿块症状。子宫肌瘤症状和健康相关生活质量问卷（UFS-QOL）是一种用于以标准化方式评估肌瘤相关症状的患者报告结局测量工具。我们的目的是将 UFS-QOL 翻译成荷兰语并进行验证。
验证研究。
由妇科医生在门诊招募患者。
患有子宫肌瘤的女性。
UFS-QOL 被翻译成荷兰语（UFS-QOL NL），并通过测试结构有效性（包括结构有效性和假设检验）、可靠性、反应性和可解释性、评估地板和天花板效应以及最小重要变化来验证其有效性。在翻译后的问卷中添加了“不适用”的选项。
191 名患有子宫肌瘤的女性在基线时、2 周后和 3 个月后完成了 UFS-QOL NL。问卷在翻译后保留了相同的因子结构（比较拟合指数 0.94-0.95；塔克-刘易斯拟合指数 0.93-0.95；均方根误差逼近 0.10-0.11），并且与其他问卷（RAND 36、医院焦虑和抑郁量表和戈洛姆布克-拉斯蒂文性满意度量表）的相关性通常为中等，与假设一致（皮尔逊 r 0.3-0.7）。我们发现，所有子量表的内部一致性信度都较高，ICC 约为 0.8-0.9。当测试手术与未手术女性之间的假设时，反应性是充分的。所有子量表的克朗巴赫α均高于 0.7，表明内部一致性较高，且无地板或天花板效应的担忧。由于不同子量表与锚定问题之间的相关性较低，因此无法计算最小重要变化。
这些结果支持 UFS-QOL NL 用于评估荷兰语女性子宫肌瘤相关症状和健康相关生活质量的测量特性。
