BMAL1 may be involved in angiogenesis and peritumoral cerebral edema of human glioma by regulating VEGF and ANG2.

The rhythm gene (Brain and Muscle ARNT-Like 1) may play an important role in glioma tolerance for anti-angiogenesis therapy. In humans with glioma of different pathological grades, expression was significantly different, and the expression of (Angiopoietin 2) and (Vascular endothelial growth factor) was positively correlated with the expression of . Additionally, expression is positively correlated with the microvascular density and peritumoral edema of glioma. According to experiments, silencing the expression of in primary glioma cells results in a decrease in the expression of . In contrast, overexpression of promotes the expression of and via pathway. Therefore, likely participates in the angiogenesis of glioma by modulating and expression, alters the therapeutic effect of anti-angiogenic treatments, and promotes peritumoral brain edema of glioma.