生物钟与癌症之间的相互作用：癌症治疗的新前沿
Interplay between Circadian Clock and Cancer: New Frontiers for Cancer Treatment.
作者信息
Sulli Gabriele, Lam Michael Tun Yin, Panda Satchidananda
机构信息
The Salk Institute for Biological Studies, La Jolla, CA, USA; Department of Medicine, Division of Regenerative Medicine, Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA; Scintillon Institute, San Diego, CA 92121, USA.
The Salk Institute for Biological Studies, La Jolla, CA, USA; Division of Pulmonary, Critical Care and Sleep Medicine, University of California San Diego, 9300 Campus Point Drive, La Jolla, CA 92037, USA.
出版信息
Trends Cancer. 2019 Aug;5(8):475-494. doi: 10.1016/j.trecan.2019.07.002. Epub 2019 Aug 3.
Circadian clocks constitute the evolutionary molecular machinery that dictates the temporal regulation of physiology to maintain homeostasis. Disruption of the circadian rhythm plays a key role in tumorigenesis and facilitates the establishment of cancer hallmarks. Conversely, oncogenic processes directly weaken circadian rhythms. Pharmacological modulation of core clock genes is a new approach in cancer therapy. The integration of circadian biology into cancer research offers new options for making cancer treatment more effective, encompassing the prevention, diagnosis, and treatment of this devastating disease. This review highlights the role of the circadian clock in tumorigenesis and cancer hallmarks, and discusses how pharmacological modulation of circadian clock genes can lead to new therapeutic options.
昼夜节律时钟构成了进化上的分子机制，它决定了维持体内平衡的生理过程的时间调节。昼夜节律的破坏在肿瘤发生中起关键作用，并促进癌症特征的形成。相反，致癌过程会直接削弱昼夜节律。核心时钟基因的药理学调节是癌症治疗中的一种新方法。将昼夜节律生物学整合到癌症研究中为提高癌症治疗效果提供了新的选择，包括对这种毁灭性疾病的预防、诊断和治疗。这篇综述强调了昼夜节律时钟在肿瘤发生和癌症特征中的作用，并讨论了昼夜节律时钟基因的药理学调节如何能够带来新的治疗选择。
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