Marinescu Adelina-Raluca, Lăzureanu Voichița, Laza Ruxandra, Musta Virgil, Nicolescu Narcisa, Cuț Talida Georgiana, Dehelean Cristina, Oancea Cristian, Licker Monica
Department XIII, 'Victor Babeș' University of Medicine and Pharmacy of Timisoara, 300041 Timisoara, Romania.
Department II, 'Victor Babeș' University of Medicine and Pharmacy of Timisoara, 300041 Timisoara, Romania.
Exp Ther Med. 2022 Jan;23(1):22. doi: 10.3892/etm.2021.10944. Epub 2021 Nov 3.
During the last decade, several changes in the epidemiology, clinical symptoms, and evolution of infection (CDI) have been reported. The number of diagnosed cases has increased, especially in individuals over 60 years of age. There has also been an increase in the share of severe forms of the disease, the number of patients with recurrent infections and the lethality caused by this condition. The aim of the present study was to determine the incidence of CDI over the past few years; to monitor the bacterial toxin by ribotyping; to observe the migration of circulating toxins; to correlate the ribotyping with the clinical form of the disease; and to correlate the treatment with the ribotyping and the clinical form. Therefore, we performed an observational retrospective study regarding the incidence of CDI at 'Victor Babeș' Hospital of Infectious Diseases and Pneumophtisiology of Timișoara, between January 2016 and December 2017. The results revealed that 210 patients were hospitalized with a diagnosis of acute enterocolitis with . All patients tested showed toxin A/B positivity. In 28 cases, the ribotyping was positive with binary toxin and hypervirulent strain 027. The tested patients were discharged or transferred from various medical/surgical clinics. In the study, we also ascertained the correlation between the clinical form of the disease and comorbidities and pre-hospital treatments as risk factors in the occurrence of the infection. In accordance with the rise of CDI during the last decade, it was possible to observe the increase in the number of infectious recurrences. From this point of view, highlighting of the ribotype in this pathology becomes a primary aspect both by increasing the success rate in curing the disease (with a reduction in the risk of recurrence) and by targeted and non-empirical administration of the antibiotic.
在过去十年中，已报道了艰难梭菌感染（CDI）在流行病学、临床症状及感染演变方面的若干变化。确诊病例数有所增加，尤其是在60岁以上人群中。该疾病严重形式的占比、反复感染患者的数量以及由此导致的致死率也有所上升。本研究的目的是确定过去几年中CDI的发病率；通过核糖体分型监测细菌毒素；观察循环毒素的迁移情况；将核糖体分型与疾病的临床形式相关联；以及将治疗方法与核糖体分型和临床形式相关联。因此，我们对2016年1月至2017年12月期间蒂米什瓦拉“维克托·巴比什”传染病与肺痨病医院的CDI发病率进行了一项观察性回顾研究。结果显示，210例患者因诊断为急性小肠结肠炎伴……而住院。所有检测患者的毒素A/B均呈阳性。在28例病例中，核糖体分型显示二元毒素和高毒力菌株027呈阳性。受试患者从各个医疗/外科诊所出院或转来。在该研究中，我们还确定了疾病的临床形式与合并症以及院前治疗作为感染发生风险因素之间的相关性。与过去十年中CDI的上升趋势一致，可以观察到感染复发次数的增加。从这一角度来看，在这种病理情况下突出核糖体分型成为一个主要方面，这既能提高疾病治愈成功率（降低复发风险），又能实现抗生素的靶向性给药而非经验性给药。
