Chow Erica, Diep Brian, Getman Tatiana, Kilani Amir, Khiatah Bashar, Jazayeri Sam, Mansour Craig
Western University of Health Sciences, Pomona, CA 91766, USA.
Community Memorial Hospital, 147 N Brent St, Ventura CA 93003, USA.
Heliyon. 2021 Nov 11;7(11):e08362. doi: 10.1016/j.heliyon.2021.e08362. eCollection 2021 Nov.
Myocardial Infarction with Nonobstructive Coronary Arteries (MINOCA), as the name implies, is an acute myocardial infarction (MI) in the absence of significant coronary artery obstruction. Diagnosis and management of such cases have been challenging. There are many etiologies of MINOCA including coronary artery spasm, coronary microvascular dysfunction, plaque disruption, spontaneous coronary thrombosis or emboli, spontaneous coronary artery dissection, or cardiomyopathies. In this paper, the pathophysiology, diagnostic work-up, and clinical management for each subtype are described, and an overarching approach on how to evaluate and manage a patient presenting with MINOCA.
非阻塞性冠状动脉心肌梗死（MINOCA），顾名思义，是指在无明显冠状动脉阻塞情况下发生的急性心肌梗死（MI）。此类病例的诊断和管理一直具有挑战性。MINOCA有多种病因，包括冠状动脉痉挛、冠状动脉微血管功能障碍、斑块破裂、自发性冠状动脉血栓形成或栓塞、自发性冠状动脉夹层，或心肌病。本文描述了每种亚型的病理生理学、诊断检查及临床管理，并给出了关于如何评估和管理MINOCA患者的总体方法。
