酮康唑的非抗真菌活性：基于生物信息学对头皮屑和脂溢性皮炎脂质代谢的假说
Ketoconazole beyond antifungal activity: Bioinformatics-based hypothesis on lipid metabolism in dandruff and seborrheic dermatitis.
作者信息
Goularte-Silva Vinicius, Paulino Luciana Campos
机构信息
Center for Natural Sciences and Humanities, Federal University of ABC, Santo André, Brazil.
出版信息
Exp Dermatol. 2022 May;31(5):821-822. doi: 10.1111/exd.14505. Epub 2021 Dec 2.
PMID:34816495
Abstract
The role of Malassezia yeasts in dandruff and seborrheic dermatitis is unclear; however, antifungal therapy with ketoconazole is commonly used. We propose that ketoconazole shifts skin lipid profile, affects Malassezia lipid metabolism and favours biotin-producing bacteria. Biotin regulates inflammatory response and cell proliferation, contributing to symptom improvement.
摘要
马拉色菌在头皮屑和脂溢性皮炎中的作用尚不清楚；然而，酮康唑抗真菌治疗是常用的。我们认为酮康唑可改变皮肤脂质谱，影响马拉色菌的脂质代谢，并有利于产生生物素的细菌生长。生物素调节炎症反应和细胞增殖，有助于症状改善。
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