Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Department of Neuropsychiatry, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
Hum Brain Mapp. 2022 Feb 15;43(3):974-984. doi: 10.1002/hbm.25699. Epub 2021 Nov 24.
Recent evidence suggests that presupplementary motor area (pre-SMA) and inferior frontal gyrus (IFG) play an important role in response inhibition. However, no study has investigated the relationship between these brain networks at resting-state and response inhibition in obsessive-compulsive disorder (OCD). We performed resting-state functional magnetic resonance imaging scans and then measured the response inhibition of 41 medication-free OCD patients and 49 healthy control (HC) participants by using the stop-signal task outside the scanner. We explored the differences between OCD and HC groups in the functional connectivity of pre-SMA and IFG associated with the ability of motor response inhibition. OCD patients showed a longer stop-signal reaction time (SSRT). Compared to HC, OCD patients exhibit different associations between the ability of motor response inhibition and the functional connectivity between pre-SMA and IFG, inferior parietal lobule, dorsal anterior cingulate cortex, insula, and anterior prefrontal cortex. Additional analysis to investigate the functional connectivity difference from the seed ROIs to the whole brain voxels revealed that, compared to HC, OCD exhibited greater functional connectivity between pre-SMA and IFG. Also, this functional connectivity was positively correlated with the SSRT score. These results provide additional insight into the characteristics of the resting-state functional connectivity of the regions belonging to the cortico-striato-thalamo-cortical circuit and the cingulo-opercular salience network, underlying the impaired motor response inhibition of OCD. In particular, we emphasize the importance of altered functional connectivity between pre-SMA and IFG for the pathophysiology of motor response inhibition in OCD.
近期的证据表明，预备运动区（pre-SMA）和额下回（IFG）在反应抑制中发挥着重要作用。然而，目前还没有研究调查强迫症（OCD）患者静息态下这些脑网络与反应抑制之间的关系。我们进行了静息态功能磁共振成像扫描，然后通过在扫描仪外使用停止信号任务来测量 41 名未服药的 OCD 患者和 49 名健康对照组（HC）参与者的反应抑制能力。我们探讨了 OCD 组和 HC 组在与运动反应抑制能力相关的 pre-SMA 和 IFG 功能连接方面的差异。OCD 患者的停止信号反应时间（SSRT）较长。与 HC 相比，OCD 患者在运动反应抑制能力与 pre-SMA 和 IFG 与下顶叶、背侧前扣带皮层、岛叶和前前额叶之间的功能连接之间的关联存在差异。进一步的分析以调查从种子 ROI 到整个大脑体素的功能连接差异表明，与 HC 相比，OCD 患者的 pre-SMA 和 IFG 之间的功能连接更强。此外，这种功能连接与 SSRT 评分呈正相关。这些结果为强迫症患者属于皮质纹状体丘脑皮质回路和扣带前扣带注意网络的静息态功能连接特征提供了额外的见解，这些特征与 OCD 患者运动反应抑制受损有关。特别是，我们强调了 pre-SMA 和 IFG 之间改变的功能连接对 OCD 患者运动反应抑制的病理生理学的重要性。
