Department of Dermatology, The First Affiliated Hospital of Xinxiang Medical University, Henan, Xinxiang 453000, China.
Department of Immunology, Xinxiang Medical University, Henan, Xinxiang 453000, China.
Arch Iran Med. 2021 Sep 1;24(9):689-695. doi: 10.34172/aim.2021.99.
Psoriasis vulgaris (PsV) is an immune-mediated skin disease of unknown mechanism. Interleukin 33 (IL-33) is a member of IL-1 cytokine family and suppression of tumorigenicity 2 (ST2) is the specific ligand of IL-33. It has been found that IL-33 and ST2 are increased in psoriatic lesions, but the expression levels in serum and their relationship to clinical features are still unclear. The aim of this study is to assess IL-33, ST2, IL-17 and IL-5 serum levels as well as serum concentration of blood glucose and blood lipids in PsV patients and their relationship with clinical characteristics.
Sixty-eight PsV samples and 60 healthy individuals were recruited. Serum levels of IL-33, ST2, IL-17 and IL-5 were measured by enzyme-linked immunosorbent assay and blood glucose and blood lipid were assayed by automatic biochemical analyzer.
Serum levels of IL-33, ST2, IL-17 and IL-5 were increased significantly in PsV patients compared with controls (<0.01). Cytokines were overexpressed in PsV patients during active stages compared with controls (<0.05). Expression levels of IL-33, ST2 and IL-17 confirmed a significance in different severity groups of PsV patients (<0.05). Serum concentration of triglyceride (TG) was also increased compared with controls (=0.024). IL-33 levels were positively correlated with total cholesterol (TC) levels (r=0.319, =0.008).
IL-33/ST2 could generally reflect the activity and disease severity in PsV patients, which indicates that the IL-33/ST2 signaling pathway plays an important role in the pathogenesis of PsV.
寻常型银屑病（PsV）是一种病因不明的免疫介导性皮肤病。白细胞介素 33（IL-33）是白细胞介素 1 细胞因子家族的一员，而抑制肿瘤发生蛋白 2（ST2）是 IL-33 的特异性配体。研究发现，IL-33 和 ST2 在银屑病皮损中表达增加，但血清中的表达水平及其与临床特征的关系尚不清楚。本研究旨在评估 PsV 患者血清中 IL-33、ST2、IL-17 和 IL-5 水平以及血糖和血脂浓度，并探讨其与临床特征的关系。
招募 68 例 PsV 样本和 60 名健康对照者。采用酶联免疫吸附试验检测血清中 IL-33、ST2、IL-17 和 IL-5 水平，采用自动生化分析仪检测血糖和血脂浓度。
与对照组相比，PsV 患者血清中 IL-33、ST2、IL-17 和 IL-5 水平显著升高（<0.01）。活动期 PsV 患者中这些细胞因子的表达高于对照组（<0.05）。IL-33、ST2 和 IL-17 的表达水平在不同严重程度的 PsV 患者中存在显著差异（<0.05）。与对照组相比，PsV 患者的甘油三酯（TG）浓度也升高（=0.024）。IL-33 水平与总胆固醇（TC）水平呈正相关（r=0.319，=0.008）。
IL-33/ST2 总体上可反映 PsV 患者的活动度和疾病严重程度，表明 IL-33/ST2 信号通路在 PsV 的发病机制中发挥重要作用。
