Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati 781039, India.
Department of Chemistry, University of Kashmir, Srinagar-190006, India.
Chem Commun (Camb). 2021 Dec 9;57(98):13221-13233. doi: 10.1039/d1cc05291h.
Pd-catalyzed C-H functionalisation affords effective synthetic tools to construct C-C and C-X bonds. Despite the challenges, the distal functionalization of C(sp)-H bonds has witnessed significant developments and the use of bidentate auxiliaries has garnished this area by providing an opportunity to control reactivity as well as selectivity beyond proximal sites. This article covers the recent developments on the Pd-catalyzed bidentate auxiliary-assisted distal C(sp)-H functionalization and is categorized based on the nature of functionalizations.
钯催化的 C-H 官能化提供了有效的合成工具，可构建 C-C 和 C-X 键。尽管存在挑战，但 C(sp)-H 键的远程官能化已经取得了重大进展，双齿辅助剂的使用通过提供控制反应性以及超越近位位点的选择性的机会，为这一领域增添了光彩。本文涵盖了钯催化的双齿辅助剂辅助的远程 C(sp)-H 官能化的最新发展，并根据官能化的性质进行了分类。
