克劳生宁，一种来自 和其果实的双咔唑类生物碱及其潜在的抗 HIV 活性。
Clausanisumine, a Prenylated Bicarbazole Alkaloid from the Fruits of and Its Potential Anti-HIV Activity.
机构信息
Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, Hainan Normal University, Haikou 571126, P. R. China.
Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, Hainan Normal University, Haikou 571126, P. R. China.
出版信息
J Org Chem. 2021 Dec 17;86(24):17722-17726. doi: 10.1021/acs.joc.1c02020. Epub 2021 Nov 24.
A unique prenylated bicarbazole alkaloid, clausanisumine (), and two biogenetically related known monomer carbazole alkaloids, mukonal () and 3-methylcarbazole (), were isolated from the fruits of . Clausanisumine () was an uncommon prenylated bicarbazole alkaloid, possessing an unprecedented carbon skeleton, which was composed of a simple carbazole alkaloid and a prenylated carbazole alkaloid. The chemical structure of was established by a combination of comprehensive spectral methods. A plausible biosynthetic pathway of was also proposed. Additionally, the potential anti-HIV activities of all isolates - were evaluated. Compound exhibited remarkable anti-HIV-1 reverse transcriptase effects showing an EC value of 18.58 nM. The discovery of the prenylated bicarbazole alkaloid from with notable anti-HIV activity would be meaningful to discovering and developing new anti-HIV drugs.
从 果实中分离得到了一个独特的prenylated bicarbazole 生物碱，clausanisumine ()，和两个生物起源相关的已知单体 carbazole 生物碱，mukonal ()和 3-methylcarbazole ()。Clausanisumine ()是一种不常见的prenylated bicarbazole 生物碱，具有前所未有的碳骨架，由一个简单的 carbazole 生物碱和一个 prenylated carbazole 生物碱组成。通过综合光谱方法确定了 的化学结构。还提出了 的可能生物合成途径。此外，对所有分离物 - 的潜在抗 HIV 活性进行了评估。化合物 表现出显著的抗 HIV-1 逆转录酶作用，EC 值为 18.58 nM。从 中发现具有显著抗 HIV 活性的 prenylated bicarbazole 生物碱，对于发现和开发新型抗 HIV 药物具有重要意义。
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