咔唑生物碱的研究进展：从分离鉴定到抗 HIV 活性评价。
Carbazole Alkaloids from : Isolation, Characterization, and Anti-HIV Evaluation.
机构信息
Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China.
The High School Affiliated to Yunnan Normal University, Kunming 650106, China.
出版信息
Molecules. 2019 Dec 26;25(1):99. doi: 10.3390/molecules25010099.
Two new carbazole alkaloids (,) and six known carbazole alkaloids (-) were isolated from . Their structures were elucidated based on extensive spectroscopic analysis. All isolated compounds (-) were evaluated for their anti-HIV effects on virus replication in MT-4 lymphocytes infected by HIV-1 Nanoluc-sec virus, and new carbazole alkaloid exhibited anti-HIV activity with an EC value of 2.4 μg/mL and SI of 7.1.
从 中分离得到两个新的咔唑生物碱（，）和六个已知的咔唑生物碱（-）。基于广泛的光谱分析确定了它们的结构。所有分离得到的化合物（-）均在感染 HIV-1 Nanoluc-sec 病毒的 MT-4 淋巴细胞中对病毒复制的抗 HIV 作用进行了评价，新的咔唑生物碱 表现出抗 HIV 活性，EC 值为 2.4 μg/mL，SI 为 7.1。
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