从黄皮果皮中提取的咔唑生物碱。
Carbazole alkaloids from the peels of Clausena lansium.
作者信息
Deng Hui-Dong, Mei Wen-Li, Wang Hui, Guo Zhi-Kai, Dong Wen-Hua, Wang Hao, Li Shao-Peng, Dai Hao-Fu
机构信息
a Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences , Haikou 571101 , China.
出版信息
J Asian Nat Prod Res. 2014 Oct;16(10):1024-8. doi: 10.1080/10286020.2014.930442. Epub 2014 Jul 4.
A new carbazole alkaloid, claulansine K (1), together with six known carbazole alkaloids (2-7), was isolated from the peels of Clausena lansium (Lour.) Skeels. The new compound was elucidated using a combination of 1D and 2D NMR (HMQC, HMBC, COSY, and ROESY) techniques, and HR-EI-MS analyses. Compound 1 showed in vitro α-glucosidase inhibitory activity with the IC50 value of 0.11 mM. Compound 2 exhibited moderate antibacterial activity against Staphylococcus aureus with the diameter of inhibition zone of 14.2 mm.
从黄皮（Clausena lansium (Lour.) Skeels）果皮中分离得到一种新的咔唑生物碱，即黄皮素K（1），以及六种已知的咔唑生物碱（2 - 7）。采用一维和二维核磁共振（HMQC、HMBC、COSY和ROESY）技术以及高分辨电子轰击质谱分析相结合的方法对新化合物进行了结构鉴定。化合物1在体外表现出α - 葡萄糖苷酶抑制活性，IC50值为0.11 mM。化合物2对金黄色葡萄球菌表现出中等抗菌活性，抑菌圈直径为14.2 mm。
Zotero 插件