PLG0206 对慢性人工关节周围感染全膝关节置换术器械的预期活性：膝关节取出物分析（KnEA）研究。
Prospective Activity of PLG0206, an Engineered Antimicrobial Peptide, on Chronic Periprosthetic Joint Infection Total Knee Arthroplasty Components : The Knee Explant Analysis (KnEA) Study.
机构信息
Peptilogics, Pittsburgh, Pennsylvania, USA.
Arthritis and Arthroplasty Design Group, Department of Orthopedic Surgery, University of Pittsburghgrid.21925.3d, Pittsburgh, Pennsylvania, USA.
出版信息
Microbiol Spectr. 2021 Dec 22;9(3):e0187921. doi: 10.1128/Spectrum.01879-21. Epub 2021 Nov 24.
Abstract
PLG0206 is an engineered antimicrobial peptide that has completed phase 1 clinical studies. A prospective study was completed on explanted implants from chronic periprosthetic joint infections ( = 17). At a concentration of 1 mg/mL for 15 min, there was a mean 4-log reduction (range, 1 to 7) in the bacterial CFU identified from the implants. Chronically infected prosthetics of the knee were exposed to PLG0206, an engineered antimicrobial peptide, at a concentration of 1 mg/mL for 15 min. A mean 4-log reduction (range, 1 to 7) in the number of bacteria occurred, which may translate to improved clinical outcomes for persons with prosthetic joint infection of the knee.
摘要
PLG0206 是一种经过工程设计的抗菌肽，已完成 1 期临床研究。对 17 例慢性人工关节周围感染（ = 17）取出的植入物进行了前瞻性研究。在浓度为 1mg/mL、作用 15min 的条件下，植入物中细菌的 CFU 数量平均减少了 4 个对数级（范围为 1 至 7）。将浓度为 1mg/mL、作用 15min 的工程抗菌肽 PLG0206 作用于膝关节慢性感染的人工假体，细菌数量平均减少了 4 个对数级（范围为 1 至 7），这可能会改善膝关节人工关节感染患者的临床预后。
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