免疫功能低下宿主中的输血获得性HIV感染

Transfusion-acquired HIV infection among immunocompromised hosts.

作者信息

Marlink R, Anderson K, Essex M, Groopman J

出版信息

Haematol Blood Transfus. 1987;31:410-3. doi: 10.1007/978-3-642-72624-8_88.

Abstract

This survey suggests that HIV infection in immunocompromised hosts is characterized by a high attack rate, short incubation time to clinical sequelae, and WB and RIP seropositivity which may precede evidence of antibodies by ELISA by weeks or months. The functional properties of patients' serum antibodies, such as neutralizing activity against HIV in vitro, may correlate with clinical course.

摘要

这项调查表明，免疫功能低下宿主中的HIV感染具有以下特点：感染率高、出现临床后遗症的潜伏期短，以及免疫印迹法（WB）和放射免疫沉淀法（RIP）血清学阳性，这可能比酶联免疫吸附测定法（ELISA）检测到抗体的证据提前数周或数月。患者血清抗体的功能特性，如体外对HIV的中和活性，可能与临床病程相关。