Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran Medical Sciences, Islamic Azad University, Yasaman Alley, Yakhchal Street, Gholhak Street, Shariati Avenue, Tehran, Iran.
Department of Clinical Pharmacy, University Hospitals of North Midlands NHS Trust, Stoke-on-Trent, ST4 6QG, UK.
Wien Klin Wochenschr. 2022 Jan;134(1-2):18-23. doi: 10.1007/s00508-021-01975-z. Epub 2021 Nov 24.
Asthma is one of the most common chronic diseases, which is a growing public health concern worldwide. In recent years, there has been an increasing number of interests in the relationship between vitamin D level and asthma control. Hence, the objective of this study was to assess the effect of high doses of vitamin D injection on asthmatic patient's respiratory condition and quality of life.
This was a single arm, before and after interventional study involving 18 patients with moderate to severe asthma. Spirometry test, St George's respiratory questionnaire (SGRQ) and serum vitamin D assay were performed. Subjects with 25-hydroxyvitamin D (25-(OH) D) < 20 ng/ml were deemed deficient (n = 18) and received 2 intramuscular injections of vitamin D 300,000 IU at monthly intervals consecutively.
The mean changes of forced expiratory volume in the first second (FEV1) were significantly different in subjects who received vitamin D injections (p = 0.008). Also, the mean changes in FEV1/forced vital capacity ratio (FEV1/FVC) were significant (p < 0.001) as well as maximum expiratory flow between 25% and 75% of FVC (MEF25-75) (p = 0.001). Interestingly, improvement in clinical parameters of SGRQ was also observed with significant differences in total score (p = 0.001). Naturally, serum vitamin D levels were increased in our patients following the injections (p < 0.001).
Our findings suggest that screening for serum 25-(OH) D deficiency is important in asthmatic patients and correction of this deficiency with high doses of vitamin D injection may lead to improvement in pulmonary function, symptoms and quality of life (QOL).
哮喘是最常见的慢性疾病之一，也是全球日益关注的公共卫生问题。近年来，人们越来越关注维生素 D 水平与哮喘控制之间的关系。因此，本研究旨在评估大剂量维生素 D 注射对哮喘患者呼吸状况和生活质量的影响。
这是一项单臂、前后干预研究，共纳入 18 例中重度哮喘患者。进行了肺量测定、圣乔治呼吸问卷（SGRQ）和血清维生素 D 检测。25-羟维生素 D（25-（OH）D）<20ng/ml 的患者被认为是缺乏（n=18），并连续每月接受 2 次肌肉注射维生素 D 300,000IU。
接受维生素 D 注射的患者用力呼气第一秒容积（FEV1）的平均变化有显著差异（p=0.008）。此外，FEV1/用力肺活量比值（FEV1/FVC）的平均变化也有显著差异（p<0.001），以及 25%至 75%用力肺活量之间的最大呼气流量（MEF25-75）（p=0.001）。有趣的是，SGRQ 的临床参数也有所改善，总分差异有统计学意义（p=0.001）。自然地，我们的患者在注射后血清维生素 D 水平升高（p<0.001）。
我们的发现表明，在哮喘患者中筛查血清 25-（OH）D 缺乏症很重要，用大剂量维生素 D 注射纠正这种缺乏症可能会改善肺功能、症状和生活质量（QOL）。
