• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

富含液体乳清的日粮对猪肠道变化的组织学评估

Histological Assessment of Intestinal Changes Induced by Liquid Whey-Enriched Diets in Pigs.

作者信息

Mhalhel Kamel, Cavallaro Mauro, Pansera Lidia, Ledesma Leyanis Herrera, Levanti Maria, Germanà Antonino, Sutera Anna Maria, Tardiolo Giuseppe, Zumbo Alessandro, Aragona Marialuisa, Montalbano Giuseppe

机构信息

Zebrafish Neuromorphology Lab, Department of Veterinary Sciences, University of Messina, 98168 Messina, Italy.

Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D'Alcontres 31, 98166 Messina, Italy.

出版信息

Vet Sci. 2025 Jul 30;12(8):716. doi: 10.3390/vetsci12080716.

DOI:10.3390/vetsci12080716
PMID:40872668
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12390096/
Abstract

Liquid whey (LW) is a nutrient-rich dairy by-product and a promising resource for animal nutrition. However, data regarding its impact on intestinal morphology and endocrine signaling are limited. Therefore, the current study aims to dissect those aspects. An experiment was conducted on 14 crossbred pigs divided into control (fed 3% of their body weight pelleted feed) and LW (fed 3% of their body weight supplemented with 1.5 L of LW) groups. The results show a significantly increased body weight gain in LW pigs during the second half of the experiment. Moreover, an increased ileal villus height, deeper crypts, and a thicker muscularis externa in the duodenum and jejunum have been reported in LW-fed pigs. Goblet cell count revealed a significant abundance of these cells in duodenal villi and jejunal crypts of the LW group, suggesting enhanced mucosal defense in all segments of LW-fed pigs. While Cholecystokinin8 and Galanin showed the same expression pattern among both groups and SI segments, the leptin expression was significantly higher in LW swine. These findings indicate that LW promotes growth, gut mucosa remodeling, and neuroendocrine signaling, thus supporting LW use as a functional dietary strategy with attention to the adaptation period.

摘要

液态乳清（LW）是一种营养丰富的乳制品副产品，也是一种很有前景的动物营养资源。然而，关于其对肠道形态和内分泌信号影响的数据有限。因此，本研究旨在剖析这些方面。对14头杂交猪进行了一项实验，将其分为对照组（饲喂占体重3%的颗粒饲料）和LW组（饲喂占体重3%的颗粒饲料并补充1.5升LW）。结果显示，在实验后半期，LW组猪的体重显著增加。此外，据报道，饲喂LW的猪回肠绒毛高度增加、隐窝加深，十二指肠和空肠的外肌层增厚。杯状细胞计数显示，LW组十二指肠绒毛和空肠隐窝中的这些细胞数量显著增多，表明饲喂LW的猪所有肠段的黏膜防御功能增强。虽然胆囊收缩素8和甘丙肽在两组和不同肠段的表达模式相同，但LW猪的瘦素表达显著更高。这些发现表明，LW可促进生长、肠道黏膜重塑和神经内分泌信号传导，因此支持将LW作为一种功能性饮食策略，但需注意适应期。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bce4/12390096/58add487833c/vetsci-12-00716-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bce4/12390096/7e2a36026659/vetsci-12-00716-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bce4/12390096/d6db6beccce5/vetsci-12-00716-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bce4/12390096/46f57402922f/vetsci-12-00716-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bce4/12390096/5547055de26e/vetsci-12-00716-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bce4/12390096/5df47dc347a2/vetsci-12-00716-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bce4/12390096/adea1e95d10c/vetsci-12-00716-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bce4/12390096/24cc828d12fa/vetsci-12-00716-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bce4/12390096/a98179cc6f31/vetsci-12-00716-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bce4/12390096/b478a4af0e8f/vetsci-12-00716-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bce4/12390096/edb3b139b7d3/vetsci-12-00716-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bce4/12390096/511f84c9695d/vetsci-12-00716-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bce4/12390096/58add487833c/vetsci-12-00716-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bce4/12390096/7e2a36026659/vetsci-12-00716-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bce4/12390096/d6db6beccce5/vetsci-12-00716-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bce4/12390096/46f57402922f/vetsci-12-00716-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bce4/12390096/5547055de26e/vetsci-12-00716-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bce4/12390096/5df47dc347a2/vetsci-12-00716-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bce4/12390096/adea1e95d10c/vetsci-12-00716-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bce4/12390096/24cc828d12fa/vetsci-12-00716-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bce4/12390096/a98179cc6f31/vetsci-12-00716-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bce4/12390096/b478a4af0e8f/vetsci-12-00716-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bce4/12390096/edb3b139b7d3/vetsci-12-00716-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bce4/12390096/511f84c9695d/vetsci-12-00716-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bce4/12390096/58add487833c/vetsci-12-00716-g012.jpg

相似文献

1
Histological Assessment of Intestinal Changes Induced by Liquid Whey-Enriched Diets in Pigs.富含液体乳清的日粮对猪肠道变化的组织学评估
Vet Sci. 2025 Jul 30;12(8):716. doi: 10.3390/vetsci12080716.
2
Size matters: lower body weight pigs have a different response to immune challenge and amino acids supplementation above the estimated requirement compared to heavy pigs.体型很重要：与体重较大的猪相比，体重较轻的猪在受到免疫挑战和补充估计需求以上的氨基酸时，会有不同的反应。
J Anim Sci. 2024 Jan 3;102. doi: 10.1093/jas/skae255.
3
Effects of wheat-based fermented liquid feed on growth performance, nutrient digestibility, gut microbiota, intestinal morphology, and barrier function in grower-finisher pigs.发酵型小麦液体饲料对生长育肥猪生长性能、养分消化率、肠道微生物区系、肠道形态和屏障功能的影响。
J Anim Sci. 2024 Jan 3;102. doi: 10.1093/jas/skae229.
4
Prescription of Controlled Substances: Benefits and Risks管制药品的处方：益处与风险
5
Dietary glycerides of valerate ameliorate diarrhea and impact intestinal physiology and serum biomarkers in weaned piglets infected with enterotoxigenic Escherichia coli F18.戊酸盐膳食甘油酯可改善感染肠产毒素性大肠杆菌 F18 的断奶仔猪的腹泻，并影响其肠道生理和血清生物标志物。
J Anim Sci. 2024 Jan 3;102. doi: 10.1093/jas/skae322.
6
Effects of β-mannanase on intestinal health and growth performance of nursery to growing pigs fed diets with DDGS.β-甘露聚糖酶对饲喂含玉米干酒糟及其可溶物日粮的保育猪至生长猪肠道健康和生长性能的影响
J Anim Sci. 2025 Jan 4;103. doi: 10.1093/jas/skaf238.
7
Dietary full-fat or defatted black soldier fly larvae can replace protein sources with no detrimental effect on growth performance or intestinal health of nursery pigs.饲用全脂或脱脂黑水虻幼虫可替代蛋白质来源，对仔猪生长性能或肠道健康无不良影响。
J Anim Sci. 2024 Jan 3;102. doi: 10.1093/jas/skae333.
8
The potential probiotic role of Lacticaseibacillus rhamnosus on growth performance, gut health, and immune responses of weaned pigs.鼠李糖乳杆菌对断奶仔猪生长性能、肠道健康和免疫反应的潜在益生菌作用。
J Anim Sci. 2025 Jan 4;103. doi: 10.1093/jas/skaf089.
9
The Black Book of Psychotropic Dosing and Monitoring.《精神药物剂量与监测黑皮书》
Psychopharmacol Bull. 2024 Jul 8;54(3):8-59.
10
Weaning age impacts intestinal stabilization of jejunal intraepithelial T lymphocytes and mucosal microbiota in pigs.断奶年龄影响猪空肠上皮内T淋巴细胞和黏膜微生物群的肠道稳定性。
BMC Vet Res. 2025 Jul 19;21(1):477. doi: 10.1186/s12917-025-04850-5.

本文引用的文献

1
Ion-Channel Proteins in the Prepubertal Bitch Reproductive System: The Immunolocalization of ASIC2, ASIC4, and PIEZO2.青春期前母犬生殖系统中的离子通道蛋白：ASIC2、ASIC4和PIEZO2的免疫定位
Int J Mol Sci. 2025 May 5;26(9):4388. doi: 10.3390/ijms26094388.
2
Gut Microbiota of Ruminants and Monogastric Livestock: An Overview.反刍动物和单胃家畜的肠道微生物群：概述
Animals (Basel). 2025 Mar 6;15(5):758. doi: 10.3390/ani15050758.
3
Gene Editing for Enhanced Swine Production: Current Advances and Prospects.用于提高猪生产性能的基因编辑：当前进展与前景
Animals (Basel). 2025 Feb 3;15(3):422. doi: 10.3390/ani15030422.
4
Localization of Piezo 1 and Piezo 2 in Lateral Line System and Inner Ear of Zebrafish ().斑马鱼（）侧线系统和内耳中 Piezo1 和 Piezo2 的定位。
Int J Mol Sci. 2024 Aug 24;25(17):9204. doi: 10.3390/ijms25179204.
5
Skeletal Muscle Metabolism Is Dynamic during Porcine Postnatal Growth.骨骼肌代谢在猪出生后生长过程中是动态变化的。
Metabolites. 2024 Jun 26;14(7):357. doi: 10.3390/metabo14070357.
6
Piezo 1 and Piezo 2 in the Chemosensory Organs of Zebrafish ().斑马鱼化学感受器官中的 Piezo1 和 Piezo2()。
Int J Mol Sci. 2024 Jul 5;25(13):7404. doi: 10.3390/ijms25137404.
7
Potential Implications of Acid-Sensing Ion Channels ASIC2 and ASIC4 in Gonadal Differentiation of Subjected to Water Temperature Increase during Gonadal Development.酸敏感离子通道ASIC2和ASIC4在性腺发育期间水温升高条件下性腺分化中的潜在影响
Animals (Basel). 2024 Mar 27;14(7):1024. doi: 10.3390/ani14071024.
8
Innovative applications of whey protein for sustainable dairy industry: Environmental and technological perspectives-A comprehensive review.乳清蛋白在可持续乳品行业中的创新应用：环境和技术视角——全面综述。
Compr Rev Food Sci Food Saf. 2024 Mar;23(2):e13319. doi: 10.1111/1541-4337.13319.
9
- Invited Review - Current status of global pig production: an overview and research trends.特邀综述——全球生猪生产现状：概述与研究趋势
Anim Biosci. 2024 Apr;37(4):719-729. doi: 10.5713/ab.23.0367. Epub 2023 Nov 2.
10
Effect of a Co-Feed Liquid Whey-Integrated Diet on Crossbred Pigs' Fecal Microbiota.共饲液体乳清综合日粮对杂交猪粪便微生物群的影响。
Animals (Basel). 2023 May 25;13(11):1750. doi: 10.3390/ani13111750.