Cavatorta A, Falzoi M, Romanelli A, Cigala F, Riccò M, Bruschi G, Franchini I, Borghetti A
Istituto di Clinica Medica e Nefrologia, Università di Parma, Italy.
J Hypertens Suppl. 1987 Dec;5(5):S463-6.
Some neuroendocrine parameters known as stress indices were examined in two groups of healthy male workers in a glass factory: the first group (60 subjects) was exposed to high environmental noise levels [greater than 90 dB(A)]; the second group (52 subjects) was exposed to low noise levels [less than 78 dB(A)]. Subjects with histories of cardiovascular diseases or high arterial pressure were excluded from the study. In both groups serum catecholamines and cortisol, and urinary vanilmandelic and homovanillic acids were evaluated at the beginning and middle of morning and afternoon work-shifts, by high performance liquid chromatography with electrochemical detection. Norepinephrine, epinephrine and vanilmandelic acid were significantly increased (P less than 0.01) during work-shifts in the group exposed to 90 dB(A), compared with baseline levels and also with catecholamine levels in the group exposed to 78 dB(A). Serum dopamine, cortisol and homovanillic acid showed no significant differences. The increased stimulation of the sympatho-adrenal system in response to high and prolonged noise exposure might lead to an abnormal response of the cardiovascular system with increasing arterial pressure values.
在一家玻璃厂的两组健康男性工人中，对一些被称为应激指标的神经内分泌参数进行了检测：第一组（60名受试者）暴露于高环境噪声水平[大于90分贝(A)]；第二组（52名受试者）暴露于低噪声水平[小于78分贝(A)]。有心血管疾病史或高血压的受试者被排除在研究之外。在两组中，通过高效液相色谱-电化学检测法，在上午和下午工作班次开始和中间时评估血清儿茶酚胺和皮质醇，以及尿香草扁桃酸和高香草酸。与基线水平以及暴露于78分贝(A)组的儿茶酚胺水平相比，暴露于90分贝(A)组在工作班次期间去甲肾上腺素、肾上腺素和香草扁桃酸显著增加（P<0.01）。血清多巴胺、皮质醇和高香草酸无显著差异。对高噪声和长时间噪声暴露的交感-肾上腺系统刺激增加，可能导致心血管系统随着动脉压值升高出现异常反应。
