Arlien-Søborg Mai C, Schmedes Astrid S, Stokholm Z A, Grynderup M B, Bonde J P, Jensen C S, Hansen Å M, Frederiksen T W, Kristiansen J, Christensen K L, Vestergaard J M, Lund S P, Kolstad H A
Department of Occupational Medicine, Danish Ramazzini Centre, Aarhus University Hospital, Nørrebrogade 44 Building 2C, 8000, Aarhus C, Denmark.
Department of Public Health, University of Copenhagen, Copenhagen, Denmark.
Int Arch Occup Environ Health. 2016 Oct;89(7):1087-93. doi: 10.1007/s00420-016-1145-3. Epub 2016 Jun 18.
Occupational and residential noise exposure has been related to increased risk of cardiovascular disease. Alteration of serum lipid levels has been proposed as a possible causal pathway. The objective of this study was to investigate the relation between ambient and at-the-ear occupational noise exposure and serum levels of total cholesterol, low-density lipoprotein-cholesterol, high-density lipoprotein-cholesterol, and triglycerides when accounting for well-established predictors of lipid levels.
This cross-sectional study included 424 industrial workers and 84 financial workers to obtain contrast in noise exposure levels. They provided a serum sample and wore portable dosimeters that every 5-s recorded ambient noise exposure levels during a 24-h period. We extracted measurements obtained during work and calculated the full-shift mean ambient noise level. For 331 workers who kept a diary on the use of a hearing protection device (HPD), we subtracted 10 dB from every noise recording obtained during HPD use and estimated the mean full-shift noise exposure level at the ear.
Mean ambient noise level was 79.9 dB (A) [range 55.0-98.9] and the mean estimated level at the ear 77.8 dB (A) [range 55.0-94.2]. Ambient and at-the-ear noise levels were strongly associated with increasing levels of triglycerides, cholesterol-HDL ratio, and decreasing levels of HDL-cholesterol, but only in unadjusted analyses that did not account for HPD use and other risk factors.
No associations between ambient or at-the-ear occupational noise exposure and serum lipid levels were observed. This indicates that a causal pathway between occupational and residential noise exposure and cardiovascular disease does not include alteration of lipid levels.
职业性和居住性噪声暴露与心血管疾病风险增加有关。血清脂质水平的改变被认为是一种可能的因果途径。本研究的目的是在考虑脂质水平的既定预测因素的情况下，调查环境噪声和耳部职业噪声暴露与总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇和甘油三酯血清水平之间的关系。
这项横断面研究纳入了424名产业工人和84名金融工作者，以获得噪声暴露水平的对比。他们提供了一份血清样本，并佩戴便携式剂量计，该剂量计每5秒记录一次24小时期间的环境噪声暴露水平。我们提取了工作期间获得的测量值，并计算了全时平均环境噪声水平。对于331名记录了听力保护装置（HPD）使用情况日记的工人，我们从HPD使用期间获得的每次噪声记录中减去10分贝，并估计耳部的全时平均噪声暴露水平。
平均环境噪声水平为79.9分贝（A）[范围55.0 - 98.9]，耳部平均估计水平为77.8分贝（A）[范围55.0 - 94.2]。环境噪声和耳部噪声水平与甘油三酯水平升高、胆固醇与高密度脂蛋白比值升高以及高密度脂蛋白胆固醇水平降低密切相关，但仅在未考虑HPD使用和其他风险因素的未调整分析中如此。
未观察到环境噪声或耳部职业噪声暴露与血清脂质水平之间存在关联。这表明职业性和居住性噪声暴露与心血管疾病之间的因果途径不包括脂质水平的改变。
