School of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
College of Food Science, South China Agricultural University, Guangzhou, Guangdong 510640, China.
Pharmacol Res. 2022 Apr;178:105974. doi: 10.1016/j.phrs.2021.105974. Epub 2021 Nov 21.
Breast cancer (BC) is the most often diagnosed cancer among females globally and has become an increasing global health issue over the last decades. Despite the substantial improvement in screening methods for initial diagnosis, effective therapy remains lacking. Still, there has been high recurrence and disease progression after treatment of surgery, endocrine therapy, chemotherapy, and radiotherapy. Considering this view, there is a crucial requirement to develop safe, freely accessible, and effective anticancer therapy for BC. The dietary bioactive compounds as auspicious anticancer agents have been recognized to be active and their implications in the treatment of BC with negligible side effects. Hence, this review focused on various dietary bioactive compounds as potential therapeutic agents in the prevention and treatment of BC with the mechanisms of action. Bioactive compounds have chemo-preventive properties as they inhibit the proliferation of cancer cells, downregulate the expression of estrogen receptors, and cell cycle arrest by inducing apoptotic settings in tumor cells. Therapeutic drugs or natural compounds generally incorporate engineered nanoparticles with ideal sizes, shapes, and enhance their solubility, circulatory half-life, and biodistribution. All data of in vitro, in vivo, and clinical studies of dietary bioactive compounds and their impact on BC were collected from Science Direct, PubMed, and Google Scholar. The data of chemopreventive and anticancer activity of dietary bioactive compounds were collected and orchestrated in a suitable place in the review. These shreds of data will be extremely beneficial to recognize a series of additional diet-derived bioactive compounds to treat BC with the lowest side effects.
乳腺癌（BC）是全球女性中最常见的癌症，在过去几十年中已成为一个日益严重的全球健康问题。尽管在初始诊断的筛查方法方面取得了实质性进展，但有效的治疗方法仍然缺乏。尽管手术后、内分泌治疗、化疗和放疗都有很高的复发和疾病进展率。考虑到这种情况，迫切需要开发安全、易于获得和有效的乳腺癌治疗方法。作为有前途的抗癌剂的膳食生物活性化合物已被认为是有效的，并且它们在治疗乳腺癌方面的应用具有很小的副作用。因此，本综述重点介绍了各种膳食生物活性化合物作为预防和治疗乳腺癌的潜在治疗剂，以及它们的作用机制。生物活性化合物具有化学预防特性，因为它们可以抑制癌细胞的增殖，下调雌激素受体的表达，并通过诱导肿瘤细胞中的凋亡来使细胞周期停滞。治疗药物或天然化合物通常将工程纳米颗粒与理想的大小、形状结合起来，并增强其溶解度、循环半衰期和生物分布。从 Science Direct、PubMed 和 Google Scholar 收集了关于膳食生物活性化合物及其对乳腺癌影响的体外、体内和临床研究的所有数据。收集并整理了膳食生物活性化合物的化学预防和抗癌活性的数据，以便在综述中合适的位置进行阐述。这些数据将非常有助于识别一系列额外的源自饮食的生物活性化合物，以最低的副作用治疗乳腺癌。
