Wen Q R, Wu M, Liu Q, Lyu J, Guo Y, Bian Z, Pei P, Du H D, Chen J S, Yu C Q, Chen Z M, Li L M
Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China.
Chinese Academy of Medical Sciences, Beijing 100730, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2021 Nov 10;42(11):1948-1954. doi: 10.3760/cma.j.cn112338-20200910-01146.
To explore the correlation between chronic diseases and muscle mass, strength and quality in adults in China. Based on the second resurvey of China Kadoorie Biobank (CKB) in 2013-2014, logistic regression models were used to analyze the correlation of different types, number and duration of chronic diseases with low muscle mass, handgrip strength and muscle quality. The prevalence rate of diabetes, coronary heart disease (CHD), stroke and chronic obstructive pulmonary disease (COPD) were 9.6%, 5.8%, 3.2% and 26.8%, respectively, and 38.8% of the participants had at least one disease, and they were more likely to have low handgrip strength and low arm muscle quality (AMQ), and the longer the chronic diseases duration, the higher the risk. The s (95%s) for low handgrip strength and low AMQ in patients with 1 chronic disease for more than 10 years was 1.64 (1.42-1.90) and 1.83 (1.60-2.10), respectively. The s (95%s) for low handgrip strength were 1.26 (1.17-1.37), 1.42 (1.23-1.64) and 2.27 (1.55-3.32) and the s (95%s) for low AMQ were 1.28 (1.18-1.38), 1.67 (1.46-1.92) and 2.41(1.69-3.45), respectively, in patients with 1, 2, ≥3 chronic diseases, the correlation showed a linear trend ( for trend <0.001). Diabetes, CHD and stroke were positively correlated with low handgrip strength and low AMQ. Compared with participants without COPD, COPD patients were more likely to have low appendicular skeletal muscle mass index (ASMI), low total skeletal muscle mass index (TSMI) and low handgrip strength, and the risk was positively correlated with disease duration. Patients with chronic diseases were more likely to have lower muscle strength and muscle quality, especially the patients with multi diseases and longer disease duration. The proportion of low handgrip strength and low AMQ was higher in patients who reported multi-prevalence and longer duration of chronic diseases.
探索中国成年人慢性病与肌肉量、力量和质量之间的相关性。基于中国嘉道理生物样本库（CKB）2013 - 2014年的第二次重复调查，采用逻辑回归模型分析不同类型、数量和病程的慢性病与低肌肉量、握力和肌肉质量的相关性。糖尿病、冠心病（CHD）、中风和慢性阻塞性肺疾病（COPD）的患病率分别为9.6%、5.8%、3.2%和26.8%，38.8%的参与者至少患有一种疾病，他们更有可能握力低和手臂肌肉质量（AMQ）低，且慢性病病程越长，风险越高。患有一种慢性病超过10年的患者，握力低和AMQ低的比值比（95%置信区间）分别为1.64（1.42 - 1.90）和1.83（1.60 - 2.10）。患1种、2种、≥3种慢性病的患者，握力低的比值比（95%置信区间）分别为1.26（1.17 - 1.37）、1.42（1.23 - 1.64）和2.27（1.55 - 3.32），AMQ低的比值比（95%置信区间）分别为1.28（1.18 - 1.38）、1.67（1.46 - 1.92）和2.41（1.69 - 3.45），相关性呈线性趋势（趋势P<0.001）。糖尿病、冠心病和中风与握力低和AMQ低呈正相关。与无COPD的参与者相比，COPD患者更有可能四肢骨骼肌质量指数（ASMI）低、总骨骼肌质量指数（TSMI）低和握力低，且风险与病程呈正相关。慢性病患者更有可能肌肉力量和质量较低，尤其是患有多种疾病且病程较长的患者。报告慢性病多患病率和病程较长的患者中，握力低和AMQ低的比例更高。
