Qi Xiaoying, Liu Bing, Jiang Zhongxiu
Department of Oncology, Shengjing Hospital of China Medical University, Shenyang, China.
Harbin University of Commerce, Harbin, China.
Nat Prod Res. 2023 Apr;37(8):1397-1400. doi: 10.1080/14786419.2021.2008388. Epub 2021 Nov 24.
From the supernatant of the fermentation broth of , we isolated a previously undescribed peniciphenalenin G () and three known compounds -. Their chemical structures were established through spectroscopic analysis as well as comparing with data in the literature. Compound displayed a moderate cytotoxicity with IC value 21.4 μM (positive drug regorafenib with IC value of 8.2 μM) against Caco2 cells while compounds and showed weak cytotoxicities with IC value of 52.1 and 39.2 μM, respectively.
从[具体来源]发酵液的上清液中，我们分离出一种此前未被描述的青霉芬内酯G（[具体名称]）以及三种已知化合物-[具体名称]。通过光谱分析并与文献数据进行比较确定了它们的化学结构。化合物[具体名称]对Caco2细胞显示出中等细胞毒性，IC值为21.4μM（阳性对照药瑞戈非尼的IC值为8.2μM），而化合物[具体名称]和[具体名称]显示出较弱的细胞毒性，IC值分别为52.1和39.2μM。
