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姜黄素改善 2 型糖尿病大鼠的肠道屏障功能、肠道微生物群和代谢性内毒素血症。

Improvement of intestinal barrier function, gut microbiota, and metabolic endotoxemia in type 2 diabetes rats by curcumin.

机构信息

Department of Endocrinology and Metabolism, Fujian Medical University Union Hospital, Fuzhou, Fujian, China.

出版信息

Bioengineered. 2021 Dec;12(2):11947-11958. doi: 10.1080/21655979.2021.2009322.

DOI:10.1080/21655979.2021.2009322
PMID:34818970
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8810160/
Abstract

Type 2 diabetes mellitus (T2DM) is known as a complex genetic disease characterized by genetic and environmental factors. The imbalanced intestinal flora and intestinal mucosal barrier are considered to be related to T2DM. Curcumin has been proved to affect the progression of T2DM. T2DM animal was established by low-dose streptozotocin intraperitoneal injection combined with high-fat diet (HFD) feeding. Hematoxylin and eosin (HE) staining and transfer electron microscopy (TEM) were used to observe morphological changes of intestinal tissues of T2DM rats. Insulin and glucose tolerance tests were performed to investigate the influence of curcumin on blood glucose. Curcumin significantly improved the intestinal integrity, hyperglycemia and insulin resistance in diabetic rats. The metabolic endotoxemia induced by HFD in diabetic rats was inhibited remarkably. Curcumin reversed gut microbiota dysbiosis in diabetic rats caused by HFD. We demonstrated that curcumin could protect intestinal mucosal barrier, improve insulin resistance and reduce blood glucose in diabetic rats. This study might provide experimental evidence for the prevention and treatment in T2DM.

摘要

2 型糖尿病（T2DM）是一种复杂的遗传疾病，其特征是遗传和环境因素。肠道菌群失衡和肠黏膜屏障被认为与 T2DM 有关。姜黄素已被证明可影响 T2DM 的进展。通过腹腔注射低剂量链脲佐菌素（STZ）联合高脂饮食（HFD）喂养建立 T2DM 动物模型。采用苏木精和伊红（HE）染色和透射电子显微镜（TEM）观察 T2DM 大鼠肠道组织的形态变化。进行胰岛素和葡萄糖耐量试验，以研究姜黄素对血糖的影响。姜黄素显著改善了糖尿病大鼠的肠道完整性、高血糖和胰岛素抵抗。HFD 诱导的糖尿病大鼠代谢性内毒素血症显著抑制。姜黄素逆转了 HFD 引起的糖尿病大鼠肠道菌群失调。我们证明姜黄素可保护糖尿病大鼠的肠黏膜屏障，改善胰岛素抵抗，降低血糖。这项研究可能为 T2DM 的预防和治疗提供实验依据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bac8/8810160/5e44964823e8/KBIE_A_2009322_F0006_OC.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bac8/8810160/ee0849d4735c/KBIE_A_2009322_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bac8/8810160/25a3fdfb4b95/KBIE_A_2009322_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bac8/8810160/4e3fa0684bdd/KBIE_A_2009322_F0003_OC.jpg
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