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褪黑素对双酚A诱导的结肠癌细胞系、正常牙龈细胞系和骨髓干细胞系细胞毒性及遗传毒性的影响。

Effects of melatonin on the Bisphenol-A- induced cytotoxicity and genetic toxicity in colon cancer cell lines, normal gingival cell lines, and bone marrow stem cell lines.

作者信息

Ebrahimi Rouya, Shokrzadeh Mohammad, Ghassemi Barghi Nasrin

机构信息

Department of Toxicology and Pharmacology, Pharmaceutical Research Center, Mazandaran University of Medical Sciences, Faculty of Pharmacy, Sari, Iran.

出版信息

Cancer Inform. 2021 Nov 17;20:11769351211056295. doi: 10.1177/11769351211056295. eCollection 2021.

DOI:10.1177/11769351211056295
PMID:34819716
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8606939/
Abstract

Bisphenol-A (BPA) is a synthetic chemical that has widely been used in the production of polycarbonate plastic and epoxy resins in the manufacture of consumer products. The most common path of human exposure to BPA is by oral intake that involves genotoxicity, oxidative stress, endocrine disruption, mutagenicity, and carcinogenicity in both and models. Melatonin is known as a free-radical scavenger and a powerful antioxidant agent. This study aimed to investigate the effects of melatonin on viability and genetic disorders of normal Human Gingival Fibroblasts (HGF), colon cancer (MKN45), and bone marrow stem cell (MSC) lines exposed to BPA. For this purpose, MTT and Comet assays were performed to evaluate the cytotoxicity and genotoxicity properties of BPA and the role of melatonin. The results showed that BPA exposure resulted in increased oxidative stress parameters including MDA and ROS, and decreased GSH content. The current study demonstrated the cytotoxicity and genotoxicity effects of BPA and the protective role of melatonin in preventing cytotoxicity and DNA damage are induced by BPA.

摘要

双酚A（BPA）是一种合成化学物质，已广泛用于消费品制造中聚碳酸酯塑料和环氧树脂的生产。人类接触双酚A最常见的途径是经口摄入，这在动物和体外模型中均涉及遗传毒性、氧化应激、内分泌干扰、致突变性和致癌性。褪黑素是一种自由基清除剂和强大的抗氧化剂。本研究旨在探讨褪黑素对暴露于双酚A的正常人牙龈成纤维细胞（HGF）、结肠癌细胞（MKN45）和骨髓干细胞（MSC）系的活力和遗传紊乱的影响。为此，进行了MTT和彗星试验，以评估双酚A的细胞毒性和遗传毒性特性以及褪黑素的作用。结果表明，暴露于双酚A会导致氧化应激参数增加，包括丙二醛（MDA）和活性氧（ROS），并降低谷胱甘肽（GSH）含量。本研究证明了双酚A的细胞毒性和遗传毒性作用，以及褪黑素在预防双酚A诱导的细胞毒性和DNA损伤方面的保护作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/719b/8606939/bdf4ae54b65b/10.1177_11769351211056295-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/719b/8606939/2c2f1b078deb/10.1177_11769351211056295-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/719b/8606939/9402bf13b894/10.1177_11769351211056295-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/719b/8606939/0cd92ced4d8d/10.1177_11769351211056295-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/719b/8606939/421101876d3e/10.1177_11769351211056295-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/719b/8606939/bdf4ae54b65b/10.1177_11769351211056295-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/719b/8606939/2c2f1b078deb/10.1177_11769351211056295-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/719b/8606939/9402bf13b894/10.1177_11769351211056295-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/719b/8606939/0cd92ced4d8d/10.1177_11769351211056295-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/719b/8606939/421101876d3e/10.1177_11769351211056295-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/719b/8606939/bdf4ae54b65b/10.1177_11769351211056295-fig5.jpg

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Melatonin Ameliorates BPA Induced Oxidative Stress in Human Red Blood Cells: An Study.
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