Li Jialu, Zhang Xiaoli, Wang Pengpeng, Li Weiping
Department of Obstetrics and Gynecology, The Second School of Clinical Medicine, Southern Medical University, Hainan Hospital of PLA General Hospital, Hainan, People's Republic of China.
Department of Obstetrics and Gynecology, Three Medical Center, Chinese PLA General Hospital, Beijing, People's Republic of China.
Pharmgenomics Pers Med. 2021 Nov 18;14:1457-1461. doi: 10.2147/PGPM.S310345. eCollection 2021.
Screening and prevention in the early stage of cervical cancer could improve the 5-year survival rate of cervical cancer by up to 90%. The occurrence rate of human papillomavirus (HPV) integration has gradually increased with the development of cervical lesions. Here, we report the case of a 43-year-old woman diagnosed with chronic cervicitis based on cervical biopsy results. After medical consultation, surgery was recommended to the patient considering her 64 HPV integration sites and other biochemical and clinical test results. The pathology result of the conical biopsy obtained during operation confirmed that both her cervix and the glands had high-grade squamous intraepithelial lesion or cervical intraepithelial neoplasia III (HSIL/CIN III). The patient underwent uterectomy and bilateral salpingectomy and was discharged thereafter. The diagnosis of the patient was revised to stage Ia1 cervical cancer. The number of HPV integration sites is suggested to be an auxiliary indicator in the early screening of cervical cancer for predicting high-grade CIN and invasive cervical cancer.
宫颈癌早期的筛查与预防可使宫颈癌的5年生存率提高近90%。随着宫颈病变的发展，人乳头瘤病毒（HPV）整合的发生率逐渐上升。在此，我们报告一例43岁女性病例，根据宫颈活检结果诊断为慢性宫颈炎。经会诊，考虑到患者有64个HPV整合位点以及其他生化和临床检查结果，建议患者进行手术。手术中获取的锥形活检病理结果证实，其宫颈及腺体均有高级别鳞状上皮内病变或宫颈上皮内瘤变III级（HSIL/CIN III）。患者接受了子宫切除术和双侧输卵管切除术，随后出院。患者的诊断修订为Ia1期宫颈癌。HPV整合位点数量被认为是宫颈癌早期筛查中预测高级别CIN和浸润性宫颈癌的一个辅助指标。
