Muhammad Adnan Y, Dhanani Rahim, Salman Summaiya, Shaikh Zeeshan, Ghaloo Shayan K, Ikram Mubasher
ENT and Head & Neck Surgery, Hayatabad Medical Complex, Peshawar, PAK.
Otolaryngology - Head and Neck Surgery, Dr. Ziauddin University & Hospital, Karachi, PAK.
Cureus. 2021 Oct 22;13(10):e18976. doi: 10.7759/cureus.18976. eCollection 2021 Oct.
Background and objective Cervical lymph node metastasis has a significant impact on the survival of patients with oral cavity tumors. The rate of occult neck node metastasis is reported to range from 20 to 40%. The depth of invasion (DOI) has been incorporated in the eighth edition of the American Joint Commission on Cancer (AJCC) staging manual and is an important predictor of cervical lymph node metastasis. In this study, we aimed to identify the occult neck node metastasis rate in early oral tongue squamous cell carcinoma (OTSCC) and correlate it with the DOI. Methods A retrospective review of all patients presenting to our facility with early-stage OTSCC was performed. Patients with tumor size of ≤4 cm and who underwent elective neck dissection at the time of surgery were included. The study outcomes were the rates of occult neck metastases in T1 and T2 OTSCC and their correlation with the DOI. Results There were 80 patients in total. Occult neck node metastases were seen in 29 (36.25%) patients. Patients with a DOI >5 mm were 1.41 times more likely to have occult neck node metastasis than those with a DOI ≤5 mm. Conclusion Occult neck node metastasis is significantly associated with the DOI. The risk of neck metastasis is higher in patients with a DOI >5 mm.
背景与目的 颈部淋巴结转移对口腔肿瘤患者的生存有重大影响。据报道，隐匿性颈部淋巴结转移率在20%至40%之间。浸润深度（DOI）已被纳入美国癌症联合委员会（AJCC）第八版分期手册，是颈部淋巴结转移的重要预测指标。在本研究中，我们旨在确定早期口腔舌鳞状细胞癌（OTSCC）的隐匿性颈部淋巴结转移率，并将其与DOI相关联。方法 对所有在我们机构就诊的早期OTSCC患者进行回顾性研究。纳入肿瘤大小≤4 cm且在手术时接受择区颈部清扫的患者。研究结果为T1和T2 OTSCC的隐匿性颈部转移率及其与DOI的相关性。结果 总共有80例患者。29例（36.25%）患者出现隐匿性颈部淋巴结转移。DOI>5 mm的患者发生隐匿性颈部淋巴结转移的可能性是DOI≤5 mm患者的1.41倍。结论 隐匿性颈部淋巴结转移与DOI显著相关。DOI>5 mm的患者颈部转移风险更高。
