典型黄酮类化合物在改善胰岛素抵抗方面的研究进展
Research progress of typical flavonoids in improving insulin resistance.
作者信息
Guo Shengnan, Zhang Li, Wu Shentao, Liu Hongyi
机构信息
The First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, China.
Tianjin Hedong Shengshi Zhongkang Hospital, China.
出版信息
Arch Med Sci Atheroscler Dis. 2020 Dec 30;5:e335-e342. doi: 10.5114/amsad.2020.103472. eCollection 2020.
Abstract
Flavonoids are a large class of compounds that are widely found in many plants, including plants used in Chinese herbal medicines. Previous studies have revealed that flavonoids possess biomedical activities, including antioxidant, anti-cancer, anti-viral, and anti-inflammatory properties. They also have the functions of lowering lipids, lowering blood sugar, and improving insulin resistance. This article selects four typical compounds of flavonoids, namely baicalin, baicalein, quercetin, and rutin, and reviews their effects and mechanisms of action in improving insulin resistance. With a view for future clinical research on flavonoids as antidiabetic drugs, we therefore provide the theoretical basis for the development and application of flavonoids.
摘要
黄酮类化合物是一大类广泛存在于许多植物中的化合物，包括用于中药材的植物。先前的研究表明，黄酮类化合物具有生物医学活性，包括抗氧化、抗癌、抗病毒和抗炎特性。它们还具有降血脂、降血糖和改善胰岛素抵抗的功能。本文选取了黄酮类化合物的四种典型化合物，即黄芩苷、黄芩素、槲皮素和芦丁，并综述了它们在改善胰岛素抵抗方面的作用效果及作用机制。鉴于未来对黄酮类化合物作为抗糖尿病药物的临床研究，我们因此为黄酮类化合物的开发和应用提供了理论依据。
相似文献
1
Research progress of typical flavonoids in improving insulin resistance.典型黄酮类化合物在改善胰岛素抵抗方面的研究进展
Arch Med Sci Atheroscler Dis. 2020 Dec 30;5:e335-e342. doi: 10.5114/amsad.2020.103472. eCollection 2020.
2
Baicalin and its aglycone: a novel approach for treatment of metabolic disorders.黄芩苷及其苷元：治疗代谢紊乱的新方法。
Pharmacol Rep. 2020 Feb;72(1):13-23. doi: 10.1007/s43440-019-00024-x. Epub 2020 Jan 8.
3
Hypoglycemic Effects of Plant Flavonoids: A Review.植物类黄酮的降血糖作用：综述
Evid Based Complement Alternat Med. 2021 Dec 8;2021:2057333. doi: 10.1155/2021/2057333. eCollection 2021.
4
Antidiabetic Potential of Flavonoids from Traditional Chinese Medicine: A Review.中药黄酮类化合物的降血糖作用：综述。
Am J Chin Med. 2019;47(5):933-957. doi: 10.1142/S0192415X19500496. Epub 2019 Jun 27.
5
Free radical scavenging and antioxidant activities of flavonoids extracted from the radix of Scutellaria baicalensis Georgi.黄芩根中黄酮类化合物的自由基清除和抗氧化活性。
Biochim Biophys Acta. 1999 Nov 16;1472(3):643-50. doi: 10.1016/s0304-4165(99)00152-x.
6
Flavonoids Derived from Chinese Medicine: Potential Neuroprotective Agents.中药来源的类黄酮：有潜力的神经保护剂。
Am J Chin Med. 2024;52(6):1613-1640. doi: 10.1142/S0192415X24500630. Epub 2024 Sep 30.
7
The flavonoid rutin and its aglycone quercetin modulate the microglia inflammatory profile improving antiglioma activity.类黄酮芦丁及其苷元槲皮素调节小胶质细胞炎症表型，提高抗神经胶质瘤活性。
Brain Behav Immun. 2020 Mar;85:170-185. doi: 10.1016/j.bbi.2019.05.003. Epub 2019 May 3.
8
Research progress of active ingredients of Scutellaria baicalensis in the treatment of type 2 diabetes and its complications.黄芩治疗 2 型糖尿病及其并发症的活性成分研究进展。
Biomed Pharmacother. 2022 Apr;148:112690. doi: 10.1016/j.biopha.2022.112690. Epub 2022 Feb 11.
9
An overview of pharmacological activities of baicalin and its aglycone baicalein: New insights into molecular mechanisms and signaling pathways.黄芩苷及其苷元黄芩素的药理活性概述：分子机制和信号通路的新见解
Iran J Basic Med Sci. 2022 Jan;25(1):14-26. doi: 10.22038/IJBMS.2022.60380.13381.
10
Bioactivity and mechanisms of flavonoids in decreasing insulin resistance.黄酮类化合物降低胰岛素抵抗的生物活性及作用机制。
J Enzyme Inhib Med Chem. 2023 Dec;38(1):2199168. doi: 10.1080/14756366.2023.2199168.
引用本文的文献
1
Aronia Melanocarpa Elliot Anthocyanins Inhibits Alcoholic Liver Disease by Activation of α7nAChR.黑果腺肋花楸果花色苷通过激活α7nAChR 抑制酒精性肝病。
Plant Foods Hum Nutr. 2024 Dec;79(4):779-794. doi: 10.1007/s11130-024-01213-7. Epub 2024 Jul 10.
2
Flavonoids intake and weight-adjusted waist index: insights from a cross-sectional study of NHANES.黄酮类化合物摄入量与体重调整腰围指数：来自美国国家健康与营养检查调查横断面研究的见解
Front Nutr. 2024 Jun 18;11:1400726. doi: 10.3389/fnut.2024.1400726. eCollection 2024.
3
Review on the Anti-Hyperglycemic Potential of and L.关于[具体植物名称]和[具体植物名称]L.的降血糖潜力综述
Plants (Basel). 2024 Jun 11;13(12):1608. doi: 10.3390/plants13121608.
本文引用的文献
1
Tangduqing Granules Attenuate Insulin Resistance and Abnormal Lipid Metabolism through the Coordinated Regulation of PPAR and DGAT2 in Type 2 Diabetic Rats.糖度清颗粒通过协调调控 2 型糖尿病大鼠的 PPAR 和 DGAT2 减轻胰岛素抵抗和异常脂质代谢。
J Diabetes Res. 2019 Mar 25;2019:7403978. doi: 10.1155/2019/7403978. eCollection 2019.
2
[Differentiated hypoglycemic effects of baicalin, berberine and puerarin on insulin-resistance HepG2 cells].[黄芩苷、黄连素和葛根素对胰岛素抵抗HepG2细胞的差异化降糖作用]
Zhongguo Zhong Yao Za Zhi. 2018 Oct;43(20):4097-4103. doi: 10.19540/j.cnki.cjcmm.20180516.001.
3
Scutellariae Radix and Coptidis Rhizoma Improve Glucose and Lipid Metabolism in T2DM Rats via Regulation of the Metabolic Profiling and MAPK/PI3K/Akt Signaling Pathway.黄芩和黄连通过调节代谢组学和 MAPK/PI3K/Akt 信号通路改善 2 型糖尿病大鼠的糖脂代谢。
Int J Mol Sci. 2018 Nov 18;19(11):3634. doi: 10.3390/ijms19113634.
4
[Effect of Rutin on Liver Function and Morphology in Type 1 Diabetes Mice Induced by Streptozotocin].[芦丁对链脲佐菌素诱导的1型糖尿病小鼠肝功能及形态的影响]
Sichuan Da Xue Xue Bao Yi Xue Ban. 2018 May;49(3):384-387.
5
[Precision medicine-oriented safety assessment strategy for traditional Chinese medicines: disease-syndrome-based toxicology].[面向精准医学的中药安全性评价策略：基于病证的毒理学]
Yao Xue Xue Bao. 2016 Nov;51(11):1681-8.
6
Disruption of tumor necrosis factor alpha receptor 1 signaling accelerates NAFLD progression in mice upon a high-fat diet.肿瘤坏死因子-α受体 1 信号通路的破坏可加速高脂饮食诱导的小鼠非酒精性脂肪性肝病进展。
J Nutr Biochem. 2018 Aug;58:17-27. doi: 10.1016/j.jnutbio.2018.04.013. Epub 2018 May 2.
7
Chrysin and baicalin in diabetic nephropathy.糖尿病肾病中的白杨素和黄芩苷。
Environ Toxicol Pharmacol. 2017 Apr;51:156-157. doi: 10.1016/j.etap.2017.02.019. Epub 2017 Feb 22.
8
Polyphenolic enriched extract of Cassia glauca Lamk, improves streptozotocin-induced type-1 diabetes linked with partial insulin resistance in rats.决明子富含多酚的提取物可改善链脲佐菌素诱导的、与大鼠部分胰岛素抵抗相关的1型糖尿病。
J Ethnopharmacol. 2017 Feb 23;198:489-498. doi: 10.1016/j.jep.2017.01.025. Epub 2017 Jan 18.
9
Inhibition of JNK suppresses autophagy and attenuates insulin resistance in a rat model of nonalcoholic fatty liver disease.抑制JNK可抑制自噬并减轻非酒精性脂肪性肝病大鼠模型中的胰岛素抵抗。
Mol Med Rep. 2017 Jan;15(1):180-186. doi: 10.3892/mmr.2016.5966. Epub 2016 Nov 24.
10
Nanostructured Lipid Carriers Loaded with Baicalin: An Efficient Carrier for Enhanced Antidiabetic Effects.载有黄芩苷的纳米结构脂质载体：一种增强抗糖尿病作用的高效载体。
Pharmacogn Mag. 2016 Jul-Sep;12(47):198-202. doi: 10.4103/0973-1296.186347.
Zotero 插件