Nirmala College of Pharmacy, Muvattupuzha, Kerala, India.
Department of Pharmacy Practice, Nirmala College of Pharmacy, 686661, Muvattupuzha, Kerala, India.
Rev Environ Health. 2020 Dec 10;36(4):467-476. doi: 10.1515/reveh-2020-0121. Print 2021 Dec 20.
The objective of the study was to identify and analyse the research done on the occurrence of cancer among pesticide applicators by conducting a systematic review of the scientific literature. PRISMA Guidelines was followed to conduct the study. Search was done in Scopus, PubMed, Embase, MEDLINE and Google Scholar databases with search terms "PESTICIDE APPLICATORS", "CANCER" using Boolean operator "AND". Meta-analysis and review articles were excluded from the study. A total of 32 studies were identified among which the average sample size was found to be 60,521. Increased RRs/ORs and positive exposure-response relationships were observed for 31 pesticides. Organophosphate and organochlorine classes of pesticides were the most to be associated with cancer. Lung cancer was observed the most followed by prostate, multiple myeloma and colon cancers among pesticide applicators. It was concluded that there is an increased risk of cancer among the pesticide applicators, whereby which bringing into focus the need to educate and train the workers on following adequate safety measures and making them aware of the hazardous chemicals. Further evaluation on the carcinogenicity of pesticides is also required.
本研究旨在通过对科学文献进行系统回顾，识别和分析有关农药施用者癌症发生的研究。本研究遵循 PRISMA 指南进行。在 Scopus、PubMed、Embase、MEDLINE 和 Google Scholar 数据库中使用“PESTICIDE APPLICATORS”和“CANCER”这两个检索词，并使用布尔运算符“AND”进行搜索。本研究排除了荟萃分析和综述文章。共确定了 32 项研究，其中平均样本量为 60521。对于 31 种农药，观察到 RR/OR 值增加和阳性暴露-反应关系。有机磷和有机氯农药类别与癌症的关联性最大。在农药施用者中，观察到肺癌最多，其次是前列腺癌、多发性骨髓瘤和结肠癌。研究结果表明，农药施用者癌症风险增加，这凸显了对工人进行适当安全措施教育和培训的必要性，并使他们意识到危险化学品的危害。还需要进一步评估农药的致癌性。
