Department of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Science. 2021 Nov 26;374(6571):1087-1092. doi: 10.1126/science.abi6087. Epub 2021 Nov 25.
The brain and gastrointestinal tract are critical sensory organs responsible for detecting, relaying, integrating, and responding to signals derived from the internal and external environment. At the interface of this sensory function, immune cells in the intestines and brain consistently survey environmental factors, eliciting responses that inform on the physiological state of the body. Recent research reveals that cross-talk along the gut-brain axis regulates inflammatory nociception, inflammatory responses, and immune homeostasis. Here, we discuss molecular and cellular mechanisms involved in the signaling of inflammation across the gut-brain axis. We further highlight interactions between the gut and the brain in inflammation-associated diseases.
大脑和胃肠道是至关重要的感觉器官，负责检测、传递、整合和响应来自内部和外部环境的信号。在这个感觉功能的界面上，肠道和大脑中的免疫细胞不断地监测环境因素，引发反应，以告知身体的生理状态。最近的研究表明，沿着肠-脑轴的相互作用调节炎症性伤害感受、炎症反应和免疫稳态。在这里，我们讨论了跨肠-脑轴信号传递中涉及的分子和细胞机制。我们还进一步强调了肠道和大脑在炎症相关疾病中的相互作用。
