Deja Stanisław, Litarski Adam, Mielko Karolina Anna, Pudełko-Malik Natalia, Wojtowicz Wojciech, Zabek Adam, Szydełko Tomasz, Młynarz Piotr
Center for Human Nutrition, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Department of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Metabolites. 2021 Nov 10;11(11):767. doi: 10.3390/metabo11110767.
Renal cell carcinoma (RCC) is the most common form of kidney malignancy. RCC is more common among men with a 2/1 male/female incidence ratio worldwide. Given the underlying epidemiological differences in the RCC incidence between males and females, we explored the gender specific H NMR serum metabolic profiles of RCC patients and their matched controls. A number of differential metabolites were shared by male and female RCC patients. These RCC specific changes included lower lactate, threonine, histidine, and choline levels together with increased levels of pyruvate, -acetylated glycoproteins, beta-hydroxybutyrate, acetoacetate, and lysine. Additionally, serum lactate/pyruvate ratio was a strong predictor of RCC status regardless of gender. Although only moderate changes in metabolic profiles were observed between control males and females there were substantial gender related differences among RCC patients. Gender specific metabolic features associated with RCC status were identified suggesting that different metabolic panels could be leveraged for a more precise diagnostic.
肾细胞癌（RCC）是最常见的肾脏恶性肿瘤形式。RCC在男性中更为常见，全球范围内男性与女性的发病率之比为2:1。鉴于男性和女性RCC发病率存在潜在的流行病学差异，我们探索了RCC患者及其匹配对照的性别特异性1H NMR血清代谢谱。男性和女性RCC患者有一些共同的差异代谢物。这些RCC特异性变化包括乳酸、苏氨酸、组氨酸和胆碱水平降低，同时丙酮酸、N-乙酰化糖蛋白、β-羟基丁酸、乙酰乙酸和赖氨酸水平升高。此外，无论性别如何，血清乳酸/丙酮酸比值都是RCC状态的有力预测指标。尽管在对照男性和女性之间仅观察到代谢谱的中度变化，但RCC患者之间存在显著的性别相关差异。确定了与RCC状态相关的性别特异性代谢特征，表明可以利用不同的代谢组进行更精确的诊断。
