沙丁胺醇通过压力定量气雾剂及间歇性正压通气用于慢性阻塞性支气管炎的治疗。
Salbutamol by pressure-packed aerosol and by intermittent positive pressure ventilation in chronic obstructive bronchitis.
作者信息
Berend N, Webster J, Marlin G E
出版信息
Br J Dis Chest. 1978 Apr;72(2):122-4. doi: 10.1016/0007-0971(78)90021-9.
PMID:348225
Abstract
The forced expiratory volume in one second (FEV1) response to salbutamol administered by pressure-packed aerosol 200 microgram, and intermittent positive pressure ventilation (IPPV), 5 and 10 mg, was determined in 60 patients with chronic bronchitis with airway obstruction. The bronchodilator response to salbutamol by IPPV was greater than by pressure-packed aerosol only in patients with severe airways obstruction and little additional benefit was gained with the 10 mg dose.
摘要
对60例患有气道阻塞的慢性支气管炎患者，测定了他们对通过压力定量气雾剂给予200微克沙丁胺醇、以及通过间歇性正压通气（IPPV）给予5毫克和10毫克沙丁胺醇后的一秒用力呼气量（FEV1）反应。仅在严重气道阻塞的患者中，IPPV给予沙丁胺醇后的支气管扩张反应大于压力定量气雾剂，且10毫克剂量几乎没有额外益处。
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