Institute for Biomedical Engineering, University of Zurich and ETH Zurich, 27219ETH Zurich, Zurich, Switzerland.
Institute for Regenerative Medicine, University of Zurich, Zurich, Switzerland.
J Cereb Blood Flow Metab. 2022 Apr;42(4):686-693. doi: 10.1177/0271678X211062274. Epub 2021 Nov 25.
There is growing evidence for the vascular contribution to cognitive impairment and dementia in Alzheimer's disease (AD) and other neurodegenerative diseases. While perfusion deficits have been observed in patients with Alzheimer's disease and tauopaties, little is known about the role of tau in vascular dysfunction. In the present study, regional cerebral blood (rCBF) was characterized in P301L mice with arterial spin labeling. No differences in rCBF in P301L mice compared to their age-matched non-transgenic littermates at mid (10-12 months of age) and advanced (19-21 months of age) disease stages. This was concomitant with preservation of cortical brain structure as assessed with structural T-weighted magnetic resonance imaging. These results show that hypoperfusion and neurodegeneration are not a phenotype of P301L mice. More studies are thus needed to understand the relationship of tau, neurodegeneration and vascular dysfunction and its modulators in AD and primary tauopathies.
越来越多的证据表明，血管因素与阿尔茨海默病（AD）和其他神经退行性疾病的认知障碍和痴呆有关。虽然在阿尔茨海默病和 tau 病患者中观察到灌注不足，但 tau 在血管功能障碍中的作用知之甚少。在本研究中，使用动脉自旋标记法对 P301L 小鼠进行了区域性脑血（rCBF）特征描述。与年龄匹配的非转基因同窝小鼠相比，P301L 小鼠在中期（10-12 个月大）和晚期（19-21 个月大）疾病阶段的 rCBF 没有差异。这与使用结构 T 加权磁共振成像评估的皮质脑结构的保存是一致的。这些结果表明，低灌注和神经退行性变不是 P301L 小鼠的表型。因此，需要更多的研究来了解 tau、神经退行性变和血管功能障碍及其在 AD 和原发性 tau 病中的调节剂之间的关系。
