Contipro a.s., Dolní Dobrouč 401, Czech Republic; Nanotechnology Centre, Centre for Energy and Environmental Technologies, VŠB - Technical University of Ostrava, 17. listopadu 2172/15, 708 00 Ostrava, Czech Republic.
Contipro a.s., Dolní Dobrouč 401, Czech Republic.
Int J Biol Macromol. 2022 Jan 1;194:726-735. doi: 10.1016/j.ijbiomac.2021.11.118. Epub 2021 Nov 22.
Nanofibrous materials are used in drug delivery as carriers of active ingredients. These can be incorporated into the materials with various electrospinning methods that differ mainly in the way spinning solutions are prepared. Each method affects primarily the encapsulation efficiency and distribution of active ingredients in the materials. This study focuses on the incorporation of octenidine dihydrochloride (OCT) and triclosan (TRI) into nanofibrous materials electrospun from native hyaluronic acid emulsions, dispersions, and blends. OCT had no substantial effect on fiber morphology, which is affected by the solvent system. All OCT encapsulation efficiencies were comparable (approximately 90%). TRI encapsulation efficiencies varied greatly depending on the method used. Merely 3% of TRI was encapsulated when it was spun from a dispersion. Encapsulation efficiency was higher, and TRI was incorporated in clusters when an emulsion was used. The best result was achieved with a blend, in which case 96% of TRI was encapsulated.
纳米纤维材料被用作药物输送的活性成分载体。这些活性成分可以通过各种静电纺丝方法与材料结合，这些方法主要在纺丝溶液的制备方式上有所不同。每种方法主要影响活性成分在材料中的包封效率和分布。本研究专注于将盐酸奥替尼啶（OCT）和三氯生（TRI）掺入由天然透明质酸乳液、分散体和共混物电纺而成的纳米纤维材料中。OCT 对纤维形态没有实质性影响，纤维形态主要受溶剂体系的影响。所有 OCT 的包封效率都相当（约 90%）。TRI 的包封效率因使用的方法而异。当从分散体中纺丝时，只有 3%的 TRI 被包裹。当使用乳液时，包封效率更高，并且 TRI 以簇的形式被掺入。在共混物中获得了最佳结果，在这种情况下，96%的 TRI 被包裹。
