Zhang Shengwei, Yang Wei, Gong Wenjian, Lu Yuhang, Yu Deng-Guang, Liu Ping
School of Health Science and Engineering, University of Shanghai for Science and Technology Shanghai 200093 China
The Base of Achievement Transformation, Shidong Hospital Affiliated to University of Shanghai for Science and Technology Shanghai 200443 China
RSC Adv. 2024 May 1;14(20):14374-14391. doi: 10.1039/d4ra01514b. eCollection 2024 Apr 25.
Burns are a global public health problem, which brings great challenges to public health and the economy. Severe burns often lead to systemic infection, shock, multiple organ failure, and even death. With the increasing demand for the therapeutic effect of burn wounds, traditional dressings have been unable to meet people's needs due to their single function and many side effects. In this context, electrospinning shows a great prospect on the way to open up advanced wound dressings that promote wound repairing and prevent infection. With its large specific surface area, high porosity, and similar to natural extracellular matrix (ECM), electrospun nanofibers can load drugs and accelerate wound healing. It provides a promising solution for the treatment and management of burn wounds. This review article introduces the concept of burn and the types of electrospun nanofibers, then summarizes the polymers used in electrospun nanofiber dressings. Finally, the drugs (plant extracts, small molecule drugs and nanoparticles) loaded with electrospun burn dressings are summarized. Some promising aspects for developing commercial electrospun burn dressings are proposed.
烧伤是一个全球性的公共卫生问题，给公共卫生和经济带来了巨大挑战。严重烧伤常导致全身感染、休克、多器官功能衰竭，甚至死亡。随着对烧伤创面治疗效果需求的增加，传统敷料因其功能单一且副作用多，已无法满足人们的需求。在此背景下，静电纺丝在开发促进伤口修复和预防感染的先进伤口敷料方面展现出巨大前景。静电纺纳米纤维具有大比表面积、高孔隙率且类似于天然细胞外基质（ECM），能够负载药物并加速伤口愈合。它为烧伤创面的治疗和管理提供了一个有前景的解决方案。这篇综述文章介绍了烧伤的概念和静电纺纳米纤维的类型，然后总结了用于静电纺纳米纤维敷料的聚合物。最后，总结了负载于静电纺烧伤敷料的药物（植物提取物、小分子药物和纳米颗粒）。并提出了开发商业化静电纺烧伤敷料的一些有前景的方向。
