胶态电解质增加脑和血清中的 GABA 水平，通过增加 NREM 睡眠和 REM 睡眠来改善睡眠，以及其成分鉴定。
Jiaotaiwan increased GABA level in brain and serum, improved sleep via increasing NREM sleep and REM sleep, and its component identification.
机构信息
Department of Traditional Chinese Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.
Wujiang District Hospital of Traditional Chinese Medicine, Suzhou, Jiangsu, 215000, China.
出版信息
J Ethnopharmacol. 2022 Mar 1;285:114866. doi: 10.1016/j.jep.2021.114866. Epub 2021 Nov 22.
ETHNOPHARMACOLOGICAL RELEVANCE
Jiaotaiwan (JTW) is good at communicating the heart and kidney. That meets the main mechanism of insomnia in traditional Chinese medicine. But the mechanism of JTW in promoting sleep is not clear.
AIM OF THE STUDY
To investigate the mechanism of JTW in promoting sleep and identify the main components.
MATERIALS AND METHODS
In this study, we detected the levels of GABA in serum and brain via LC-MS/MS analysis and investigated the hypnotic effect of JTW and its role in promoting sleep via Sleep monitoring and vigilance state analysis. Further, the identification of the main components was carried out by using LC-MS/MS analysis.
RESULTS
JTW could increase the GABA levels in serum, FC and BS of SDM rats. JTW reduced the amount of wakefulness, increased the time of NREM sleep and REM sleep. A total of 25 compounds were identified.
CONCLUSIONS
The current work provides valuable information on the hypnotic effects of JTW and its regulatory mechanisms in promoting sleep.
民族药理学相关性
交泰丸擅长沟通心肾。这符合中医失眠的主要机制。但交泰丸促进睡眠的机制尚不清楚。
研究目的
探讨交泰丸促进睡眠的作用机制，鉴定主要成分。
材料和方法
在这项研究中，我们通过 LC-MS/MS 分析检测了血清和脑组织中 GABA 的水平，并通过睡眠监测和警觉状态分析研究了交泰丸的催眠作用及其促进睡眠的作用。此外，还通过 LC-MS/MS 分析鉴定了主要成分。
结果
交泰丸可提高 SDM 大鼠血清、FC 和 BS 中的 GABA 水平。交泰丸减少了觉醒量，增加了 NREM 睡眠和 REM 睡眠的时间。共鉴定出 25 种化合物。
结论
目前的工作为交泰丸的催眠作用及其促进睡眠的调节机制提供了有价值的信息。
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