愤怒管理：动物攻击行为中谷氨酸受体介导的突触可塑性机制。
Anger management: Mechanisms of glutamate receptor-mediated synaptic plasticity underlying animal aggression.
机构信息
Department of Physiology, Southern Illinois University School of Medicine, Carbondale, IL 62901, USA.
出版信息
Int J Biochem Cell Biol. 2022 Jan;142:106120. doi: 10.1016/j.biocel.2021.106120. Epub 2021 Nov 23.
Abstract
Excessive and recurring violent aggression is a serious concern for society and a symptom of many psychiatric diseases. Substance abuse, attack experience, and social and traumatic stress increase vulnerability to developing this type of aggression. Glutamate receptors are an intriguing target for long-term treatment. This review will assess the importance of glutamate receptors and glutamatergic pathways in aggression, focusing on the role of glutamate receptor-mediated synaptic plasticity in experience-dependent long-lasting aggression. By synthesizing what is known about glutamatergic systems in aggression, it is hoped more effective treatments can be developed.
摘要
过度和反复的暴力攻击是社会关注的严重问题，也是许多精神疾病的症状。物质滥用、攻击经历以及社会和创伤性压力会增加患上这种类型攻击的脆弱性。谷氨酸受体是长期治疗的一个有趣目标。本综述将评估谷氨酸受体和谷氨酸能途径在攻击中的重要性，重点关注谷氨酸受体介导的突触可塑性在经验依赖性长期攻击中的作用。通过综合了解攻击行为中的谷氨酸能系统，希望能开发出更有效的治疗方法。
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