小脑退行性变相关蛋白 CDR2 和 CDR2L 在人脑和鼠脑组织中的表达。
Expression of cerebellar degeneration-related proteins CDR2 and CDR2L in human and rat brain tissue.
机构信息
Department of Neurology, Haukeland University Hospital, Pb 1400, 5021 Bergen, Norway; Department of Clinical Medicine, University of Bergen, Pb 7804, 5020 Bergen, Norway.
Department of Clinical Medicine, University of Bergen, Pb 7804, 5020 Bergen, Norway.
出版信息
J Neuroimmunol. 2022 Jan 15;362:577766. doi: 10.1016/j.jneuroim.2021.577766. Epub 2021 Nov 11.
Patients with ovarian cancer and paraneoplastic cerebellar degeneration, a cancer-related immune disorder, often have anti-Yo antibody. Here we studied the distributions of anti-Yo antigens CDR2L and CDR2 in rat and human brain using immunohistochemistry and western blot. CDR2L localized mainly to the Purkinje cells and large neurons scattered in the brain stem. CDR2 was detected in vascular smooth muscle cells of rat and human and in cells lining the ventricle system in rats. The observed distribution of CDR2L is compatible with the hypothesis that this antigen is the major target of anti-Yo. CDR2 and CDR2L are expressed by different cell subtypes.
患有卵巢癌和副肿瘤性小脑变性（一种与癌症相关的免疫紊乱）的患者通常具有抗 Yo 抗体。在这里，我们使用免疫组织化学和 Western blot 研究了大鼠和人脑中抗 Yo 抗原 CDR2L 和 CDR2 的分布。CDR2L 主要定位于小脑浦肯野细胞和散在脑干中的大神经元。CDR2 存在于大鼠和人类的血管平滑肌细胞以及大鼠脑室系统的细胞中。观察到的 CDR2L 分布与该抗原是抗 Yo 的主要靶标这一假说一致。CDR2 和 CDR2L 由不同的细胞亚型表达。
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