Division of Cardiac Surgery, Yale School of Medicine, New Haven, Connecticut, USA; Center for Outcomes Research and Evaluation, Yale New Haven Hospital, New Haven, Connecticut, USA.
Center for Outcomes Research and Evaluation, Yale New Haven Hospital, New Haven, Connecticut, USA; Columbia University Irving Medical Center/NewYork-Presbyterian Hospital and the Cardiovascular Research Foundation, New York, New York, USA.
J Am Coll Cardiol. 2021 Nov 30;78(22):2161-2172. doi: 10.1016/j.jacc.2021.09.855.
Recent trends, including survival beyond 30 days, in aortic valve replacement (AVR) following the expansion of indications for transcatheter aortic valve replacement (TAVR) are not well-understood.
The authors sought to characterize the trends in characteristics and outcomes of patients undergoing AVR.
The authors analyzed Medicare beneficiaries who underwent TAVR and SAVR in 2012 to 2019. They evaluated case volume, demographics, comorbidities, 1-year mortality, and discharge disposition. Cox proportional hazard models were used to assess the annual change in outcomes.
Per 100,000 beneficiary-years, AVR increased from 107 to 156, TAVR increased from 19 to 101, whereas SAVR declined from 88 to 54. The median [interquartile range] age remained similar from 77 [71-83] years to 78 [72-84] years for overall AVR, decreased from 84 [79-88] years to 81 [75-86] years for TAVR, and decreased from 76 [71-81] years to 72 [68-77] years for SAVR. For all AVR patients, the prevalence of comorbidities remained relatively stable. The 1-year mortality for all AVR decreased from 11.9% to 9.4%. Annual change in the adjusted odds of 1-year mortality was 0.93 (95% CI: 0.92-0.94) for TAVR and 0.98 (95% CI: 0.97-0.99) for SAVR, and 0.94 (95% CI: 0.93-0.95) for all AVR. Patients discharged to home after AVR increased from 24.2% to 54.7%, primarily driven by increasing home discharge after TAVR.
The advent of TAVR has led to about a 60% increase in overall AVR in older adults. Improving outcomes in AVR as a whole following the advent of TAVR with increased access is a reassuring trend.
经导管主动脉瓣置换术(TAVR)适应证扩大后,主动脉瓣置换术(AVR)患者的 30 天生存率等近期趋势尚不清楚。
作者旨在描述接受 AVR 治疗的患者特征和结局的变化趋势。
作者分析了 2012 年至 2019 年期间接受 TAVR 和 SAVR 的 Medicare 受益人的数据。他们评估了病例量、人口统计学特征、合并症、1 年死亡率和出院去向。采用 Cox 比例风险模型评估结局的年度变化。
每 10 万受益人数,AVR 从 107 例增至 156 例,TAVR 从 19 例增至 101 例,而 SAVR 从 88 例降至 54 例。总体 AVR 的中位(四分位距)年龄从 77 岁[71-83]岁到 78 岁[72-84]岁保持不变,TAVR 从 84 岁[79-88]岁降至 81 岁[75-86]岁,SAVR 从 76 岁[71-81]岁降至 72 岁[68-77]岁。所有接受 AVR 治疗的患者的合并症患病率保持相对稳定。所有 AVR 患者的 1 年死亡率从 11.9%降至 9.4%。TAVR 的调整后 1 年死亡率的年变化率为 0.93(95%CI:0.92-0.94),SAVR 为 0.98(95%CI:0.97-0.99),所有 AVR 为 0.94(95%CI:0.93-0.95)。AVR 后出院回家的患者比例从 24.2%增至 54.7%,主要是由于 TAVR 后出院回家的比例增加。
TAVR 的出现使老年患者的总体 AVR 增加了约 60%。随着 TAVR 适应证扩大后获得更多的治疗机会,整体 AVR 结局改善是一个令人欣慰的趋势。