Comprehensive Smoking Treatment Program, Penn Lung Center, Suite 251 Wright-Saunders Building, 51 North 39th Street, Philadelphia, PA, USA; Abramson Cancer Center, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA.
Comprehensive Smoking Treatment Program, Penn Lung Center, Suite 251 Wright-Saunders Building, 51 North 39th Street, Philadelphia, PA, USA.
Med Clin North Am. 2022 Jan;106(1):99-112. doi: 10.1016/j.mcna.2021.08.011.
Tobacco use disorder is highly prevalent; more than a billion individuals use tobacco worldwide. Popular views on the addictive potential of tobacco often underestimate the complex neural adaptations that underpin continued use. Although sometimes trivialized as a minor substance, effects of nicotine on behavior lead to profound morbidity over a lifetime of exposure. Innovations in processing have led to potent forms of tobacco and delivery devices. Proactive treatment strategies focus on pharmacotherapeutic interventions. Innovations on the horizon hold promise to help clinicians address this problem in a phenotypically tailored manner. Efforts are needed to prevent tobacco use for future generations.
烟草使用障碍的发病率极高；全球有超过 10 亿人使用烟草。人们对烟草潜在成瘾性的普遍看法往往低估了支撑持续使用的复杂神经适应。尽管尼古丁对行为的影响有时被轻视为一种次要物质，但在一生中持续暴露于尼古丁下，会导致严重的发病率。加工技术的创新导致了更有效的烟草形式和输送装置。积极的治疗策略侧重于药物治疗干预。即将出现的创新有望帮助临床医生以表型定制的方式解决这一问题。需要努力防止后代使用烟草。
