驱动抗体受体和 RING E3 连接酶 TRIM21 进行细胞内中和的分子机制。
The molecular mechanisms that drive intracellular neutralization by the antibody-receptor and RING E3 ligase TRIM21.
机构信息
MRC Laboratory of Molecular Biology, UK.
出版信息
Semin Cell Dev Biol. 2022 Jun;126:99-107. doi: 10.1016/j.semcdb.2021.11.005. Epub 2021 Nov 22.
PMID:34823983
Abstract
The cytosolic antibody receptor and RING E3 ligase TRIM21 targets intracellular, antibody-coated immune complexes for degradation and activates the immune system. Here we review how TRIM21 degrades diverse targets and how this activity can be exploited in molecular biology and for the development of new therapeutics. In addition, we compare what is known about TRIM21's mechanism to other TRIM proteins and RING E3 ligases.
摘要
细胞质抗体受体和 RING E3 连接酶 TRIM21 靶向细胞内的抗体包被免疫复合物进行降解，并激活免疫系统。在这里，我们回顾了 TRIM21 如何降解不同的靶标，以及这种活性如何在分子生物学和新疗法的开发中得到利用。此外，我们将 TRIM21 的机制与其他 TRIM 蛋白和 RING E3 连接酶进行了比较。
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