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血管紧张素 II:心脏环境中血管扩张的多模式方法。

Angiotensin II: A Multimodal Approach to Vasoplegia in a Cardiac Setting.

机构信息

Baylor University Medical Center, Dallas, Texas, US.

Texas A&M University College of Medicine, Bryan, Texas, US.

出版信息

Methodist Debakey Cardiovasc J. 2021 Nov 3;17(4):98-101. doi: 10.14797/mdcvj.576. eCollection 2021.

DOI:10.14797/mdcvj.576
PMID:34824689
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8588748/
Abstract

Patients experiencing vasoplegia, a type of distributive shock, have limited options when conventional vasopressors are not appropriate or sufficient. This is especially true for patients with cardiac dysfunction, whether after heart transplant or ventricular assist device (VAD) implantation. Angiotensin II has been used in various clinical settings for distributive shock; however, its role in patients after orthotopic heart transplant or VAD implantation is not well studied. We present two cases where angiotensin II played a vital role in correcting vasoplegia for critical cardiac patients.

摘要

患者出现血管扩张性休克(一种分布性休克)时,如果常规血管加压药不合适或效果不佳,选择有限。对于伴有心功能障碍的患者,这种情况尤其如此,无论是心脏移植后还是心室辅助装置(VAD)植入后。血管紧张素 II 已在各种临床情况下用于分布性休克;然而,其在原位心脏移植或 VAD 植入后患者中的作用尚未得到充分研究。我们介绍了两例血管扩张性休克危重心血管患者中血管紧张素 II 发挥重要作用的病例。

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本文引用的文献

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Angiotensin II: A Review of Current Literature.血管紧张素 II:文献综述。
J Cardiothorac Vasc Anesth. 2022 Apr;36(4):1180-1187. doi: 10.1053/j.jvca.2021.07.021. Epub 2021 Jul 16.
2
Underutilized Fuel: Angiotensin II for Vasoplegia in the Heart Failure Patient Population.
J Cardiothorac Vasc Anesth. 2021 Dec;35(12):3843. doi: 10.1053/j.jvca.2021.04.005. Epub 2021 Apr 10.
3
2021 Update to the 2017 ACC Expert Consensus Decision Pathway for Optimization of Heart Failure Treatment: Answers to 10 Pivotal Issues About Heart Failure With Reduced Ejection Fraction: A Report of the American College of Cardiology Solution Set Oversight Committee.《2017年美国心脏病学会(ACC)心力衰竭治疗优化专家共识决策路径2021年更新:关于射血分数降低的心力衰竭的10个关键问题解答:美国心脏病学会解决方案集监督委员会报告》
J Am Coll Cardiol. 2021 Feb 16;77(6):772-810. doi: 10.1016/j.jacc.2020.11.022. Epub 2021 Jan 11.
4
Treatment With Angiotensin II Is Associated With Rapid Blood Pressure Response and Vasopressor Sparing in Patients With Vasoplegia After Cardiac Surgery: A Post-Hoc Analysis of Angiotensin II for the Treatment of High-Output Shock (ATHOS-3) Study.血管扩张性休克治疗(ATHOS-3)研究的事后分析:血管扩张性心脏病手术后患者应用血管紧张素 II 治疗与血压快速反应和血管加压素节省相关。
J Cardiothorac Vasc Anesth. 2021 Jan;35(1):51-58. doi: 10.1053/j.jvca.2020.08.001. Epub 2020 Aug 7.
5
Vasoplegic syndrome following cardiothoracic surgery-review of pathophysiology and update of treatment options.心胸外科手术后血管麻痹综合征:病理生理学综述及治疗选择更新。
Crit Care. 2020 Feb 4;24(1):36. doi: 10.1186/s13054-020-2743-8.
6
Vasoplegia treatments: the past, the present, and the future.血管扩张治疗:过去、现在和未来。
Crit Care. 2018 Feb 27;22(1):52. doi: 10.1186/s13054-018-1967-3.
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N Engl J Med. 2017 Aug 3;377(5):419-430. doi: 10.1056/NEJMoa1704154. Epub 2017 May 21.