依诺肝素与利伐沙班在关节置换术中预防深静脉血栓形成的比较
Comparison of Enoxaparin and Rivaroxaban in the Prophylaxis of Deep Venous Thrombosis in Arthroplasty.
作者信息
Çiçek Necati, Ağir İsmail, Tosun Hacı Bayram, Uludağ Abuzer, Sari Abdulkadir
机构信息
Department of Orthopedics and Traumatology, Adıyaman Training and Research Hospital, Adıyaman, Turkey.
Department of Orthopedics and Traumatology, Adiyaman University, School of Medicine, Adıyaman, Turkey.
出版信息
Emerg Med Int. 2021 Nov 16;2021:2945978. doi: 10.1155/2021/2945978. eCollection 2021.
BACKGROUND
Pulmonary embolism is a serious early complication of arthroplasty procedures that can develop after deep venous thrombosis. The present study aimed to compare rivaroxaban and enoxaparin in terms of preventing DV and PE, and also in this study, we compared the complications due to these drugs in patients undergoing elective arthroplasty.
MATERIALS AND METHODS
214 patients were divided into three groups based on their treatment regimens. In group I, enoxaparin was used, in group II, rivaroxaban was used, and in group III, enoxaparin was used throughout hospitalization, and after hospital discharge, rivaroxaban was used. These three groups were compared according to the occurrence of deep venous thrombosis, pulmonary embolism, and major and minor complications.
RESULTS
Major postoperative complications occurred in 5, 15, and 6 patients in group I, II, and III, respectively. Minor postoperative complications occurred in 10, 24, and 11 patients in group I, II, and III, respectively. No significant difference was found among the three groups. Deep venous thrombosis or pulmonary embolism was not observed in any patient.
CONCLUSION
Rivaroxaban was found to be as effective as enoxaparin in the prevention of deep venous thrombosis and other complications after arthroplasty. Moreover, oral rivaroxaban provided greater ease of use compared to subcutaneous enoxaparin. Based on these findings, we consider that rivaroxaban could be an effective alternative to enoxaparin.
背景
肺栓塞是关节置换手术严重的早期并发症，可在深静脉血栓形成后发生。本研究旨在比较利伐沙班和依诺肝素在预防深静脉血栓和肺栓塞方面的效果，同时在本研究中，我们还比较了这些药物在接受择期关节置换手术患者中的并发症情况。
材料与方法
214例患者根据治疗方案分为三组。第一组使用依诺肝素，第二组使用利伐沙班，第三组在住院期间使用依诺肝素，出院后使用利伐沙班。根据深静脉血栓形成、肺栓塞以及主要和次要并发症的发生情况对这三组进行比较。
结果
第一组、第二组和第三组分别有5例、15例和6例患者发生主要术后并发症。第一组有10例、第二组有24例、第三组有11例患者发生次要术后并发症。三组之间未发现显著差异。未观察到任何患者发生深静脉血栓或肺栓塞。
结论
发现利伐沙班在预防关节置换术后深静脉血栓和其他并发症方面与依诺肝素同样有效。此外，与皮下注射依诺肝素相比，口服利伐沙班使用起来更加方便。基于这些发现，我们认为利伐沙班可以成为依诺肝素的有效替代药物。
Zotero 插件