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用于微流体的形状可编程人工纤毛

Shape-programmable artificial cilia for microfluidics.

作者信息

Panigrahi Bivas, Sahadevan Vignesh, Chen Chia-Yuan

机构信息

Department of Refrigeration, Air Conditioning and Energy Engineering, National Chin-Yi University of Technology, Taichung 411, Taiwan.

Department of Mechanical Engineering, National Cheng Kung University, No. 1 University Road, Tainan 701, Taiwan.

出版信息

iScience. 2021 Oct 28;24(12):103367. doi: 10.1016/j.isci.2021.103367. eCollection 2021 Dec 17.

DOI:10.1016/j.isci.2021.103367
PMID:34825146
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8605101/
Abstract

The artificial ciliary motion has been known not to be hydrodynamically optimal, limiting their associated applications in the microscale flow domain. One of the major hurdles of contemporary artificial cilia is its structural rigidity, which restricts their flexibility. To address this issue, this work proposed a shape-programmable artificial cilia design with distinctive polydimethylsiloxane (PDMS) and magnetic segments distributed throughout the structure, which provided precise control for time-spatial modulation of the whole artificial cilia structure under external magnetic actuation. For the fabrication of the proposed multi-segment artificial cilia, a facile microfabrication process with stepwise mold blocking followed by the PDMS and magnetic composite casting was adopted. The hydrodynamic analysis further elucidated that the proposed artificial cilia beating induced significant flow disturbance within the flow field, and the associated application was demonstrated through an efficient mixing operation.

摘要

已知人工纤毛运动在流体动力学方面并非最优,这限制了它们在微尺度流动领域的相关应用。当代人工纤毛的主要障碍之一是其结构刚性,这限制了它们的灵活性。为了解决这个问题,这项工作提出了一种形状可编程的人工纤毛设计,其具有独特的聚二甲基硅氧烷(PDMS)和分布在整个结构中的磁性段,这在外部磁驱动下为整个人工纤毛结构的时空调制提供了精确控制。对于所提出的多段人工纤毛的制造,采用了一种简便的微制造工艺,即先进行逐步模具封堵,然后进行PDMS和磁性复合材料浇铸。流体动力学分析进一步阐明,所提出的人工纤毛摆动在流场内引起了显著的流动扰动,并通过高效混合操作展示了其相关应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fd5/8605101/0af27241649b/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fd5/8605101/b9c84729457e/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fd5/8605101/585ca4de1b7b/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fd5/8605101/f96166833980/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fd5/8605101/81322460f30d/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fd5/8605101/0af27241649b/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fd5/8605101/b9c84729457e/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fd5/8605101/585ca4de1b7b/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fd5/8605101/f96166833980/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fd5/8605101/81322460f30d/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fd5/8605101/0af27241649b/gr4.jpg

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2
Millimeter-scale flexible robots with programmable three-dimensional magnetization and motions.具有可编程三维磁化和运动的毫米级柔性机器人。
Sci Robot. 2019 Apr 24;4(29). doi: 10.1126/scirobotics.aav4494.
3
Controlled Multidirectional Particle Transportation by Magnetic Artificial Cilia.磁性人工纤毛实现的可控多向粒子输运
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4
Microfluidic Applications of Artificial Cilia: Recent Progress, Demonstration, and Future Perspectives.人工纤毛的微流控应用:最新进展、演示及未来展望
Micromachines (Basel). 2022 May 3;13(5):735. doi: 10.3390/mi13050735.
5
An aquatic microrobot for microscale flow manipulation.用于微尺度流控的水下微型机器人。
Sci Rep. 2022 Mar 23;12(1):5041. doi: 10.1038/s41598-022-07938-2.
ACS Nano. 2020 Aug 25;14(8):10313-10323. doi: 10.1021/acsnano.0c03801. Epub 2020 Aug 4.
4
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5
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6
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