School of Environmental and Biological Engineering, Nanjing University of Science and Technology, 200 Xiaolingwei Street, Nanjing, 210094, China.
School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, 639798, Singapore.
Macromol Rapid Commun. 2022 Mar;43(5):e2100776. doi: 10.1002/marc.202100776. Epub 2021 Dec 16.
The transportation of sweat in an epidermal sweat sensor is critical for the monitoring of biochemical compositions of human sweat. However, it is still a challenge to engineer microfluidic devices with super-wetting channels for such epidermal sweat sensors. Herein, a zwitterionic poly (2-methacryloyloxyethyl phosphorylcholine) (PMPC) modified microfluidic device with super-wetting and good liquid transport ability via an azo coupling reaction of PMPC onto the surface of polydimethylsiloxane microfluidic devices is reported. The obtained PMPC-modified microfluidic device can be integrated with flexible electrochemical sensor to measure the ion compositions of human sweat in real-time. The super-hydrophilic zwitterionic polymer surface modification can greatly facilitate the transportation of body fluids in microfluidic sensors for the detection of various biomarkers. Such microfluidic sensors have great potential for next-generation personalized healthcare.
在表皮汗液传感器中，汗液的传输对于监测人体汗液的生化成分至关重要。然而，对于这种表皮汗液传感器，工程化具有超润湿通道的微流控器件仍然是一个挑战。在此，通过聚二甲基硅氧烷微流控器件表面的偶氮偶联反应，报道了一种带有两性离子聚（2-甲基丙烯酰氧乙基磷酸胆碱）（PMPC）的改性微流控器件，具有超润湿和良好的液体传输能力。所得到的 PMPC 修饰的微流控器件可以与柔性电化学传感器集成，以实时测量人体汗液的离子组成。超亲水两性离子聚合物表面修饰极大地方便了微流控传感器中体液的传输，用于检测各种生物标志物。这种微流控传感器在下一代个性化医疗保健方面具有巨大的潜力。
