Centre for Research on Exercise, Physical Activity, and Health (CREXPAH), School of Human Movement and Nutrition Sciences, University of Queensland, Brisbane, Australia.
Physiology and Ultrasound Laboratory in Science and Exercise (PULSE), School of Human Movement and Nutrition Sciences, University of Queensland, Brisbane, Australia.
Scand J Med Sci Sports. 2022 Mar;32(3):512-520. doi: 10.1111/sms.14106. Epub 2021 Dec 9.
To compare the short- and long-term effects of high-intensity interval training (HIIT) with usual care moderate intensity continuous training (MICT) on systemic vascular function and stiffness in patients with coronary artery disease undergoing a cardiac rehabilitation program.
Randomized controlled trial.
Fifty-four patients (age = 63 ± 8 years, 93% male) were randomized to complete 3 sessions/week (2 supervised, 1 home-based) of either (1) 4 × 4-min HIIT or (2) 40-min MICT, for 4 weeks. Patients then continued 3 unsupervised home-based sessions/week of their allocated training for 11 months. Brachial artery flow-mediated dilation, pulse wave velocity, and blood pressure were measured at baseline, 4 weeks, 3 months, 6 months, and 12 months. Data were analyzed using linear mixed modeling and are presented as mean change from baseline (95% CI).
HIIT showed a greater improvement in flow-mediated dilation compared to MICT after 4 weeks [1.5% (0.9, 2.1) vs 0.1% (-0.5, 0.8); p = 0.004) but not 12 months [1.2% (-0.2, 2.5) vs 0.4% (-0.8, 1.7); p = 0.153). There were no short- or long-term group differences for changes in pulse wave velocity, peripheral or central blood pressure between HIIT and MICT after 4 weeks, or over 12 months.
A 4-week HIIT program was superior to MICT for improving vascular function, but not arterial stiffness or blood pressure. Over 12 months, changes in vascular function, blood pressure, and arterial stiffness were similar for HIIT and MICT.
比较高强度间歇训练（HIIT）与常规中等强度持续训练（MICT）对接受心脏康复计划的冠心病患者全身血管功能和僵硬度的短期和长期影响。
随机对照试验。
54 名患者（年龄=63±8 岁，93%为男性）被随机分为 3 组，每周完成 3 次训练（2 次监督，1 次家庭训练），分别为：（1）4×4 分钟 HIIT，或（2）40 分钟 MICT，持续 4 周。然后，患者继续进行 11 个月的每周 3 次非监督家庭训练。在基线、4 周、3 个月、6 个月和 12 个月时测量肱动脉血流介导的扩张、脉搏波速度和血压。采用线性混合模型进行数据分析，结果以从基线的平均变化（95%CI）表示。
与 MICT 相比，HIIT 在 4 周后血流介导的扩张改善更大[1.5%（0.9，2.1）比 0.1%（-0.5，0.8）；p=0.004]，但在 12 个月时没有差异[1.2%（-0.2，2.5）比 0.4%（-0.8，1.7）；p=0.153]。在 4 周后或 12 个月时，HIIT 和 MICT 之间在脉搏波速度、外周或中心血压的变化方面，短期和长期均无组间差异。
与 MICT 相比，4 周的 HIIT 方案更能改善血管功能，但不能改善动脉僵硬或血压。在 12 个月时，HIIT 和 MICT 对血管功能、血压和动脉僵硬的变化相似。
