低容量联合有氧和阻力高强度间歇训练对 2 型糖尿病患者血管健康的影响：一项随机对照试验。
Effect of low-volume combined aerobic and resistance high-intensity interval training on vascular health in people with type 2 diabetes: a randomised controlled trial.
机构信息
Physiology and Ultrasound Laboratory in Science and Exercise, School of Human Movement and Nutrition Sciences, The University of Queensland, St Lucia, Queensland, Australia.
Centre for Research on Exercise, Physical Activity and Health, School of Human Movement and Nutrition Sciences, The University of Queensland, St Lucia, Queensland, Australia.
出版信息
Eur J Appl Physiol. 2024 Sep;124(9):2819-2833. doi: 10.1007/s00421-024-05473-8. Epub 2024 May 2.
PURPOSE
We compared the effects of low-volume combined aerobic and resistance high-intensity interval training (C-HIIT), combined moderate-intensity continuous training (C-MICT) and waitlist control (CON) on vascular health after 8-weeks of supervised training, and an additional 10-months of self-directed training, in adults with type 2 diabetes (T2D).
METHODS
Sixty-nine low active adults with T2D were randomised to 8-weeks of supervised C-HIIT (3 times/week, 78-min/week), C-MICT (current exercise guidelines, 4 times/week, 210-min/week) or CON. CON underwent usual care for 8-weeks before being re-randomised to C-HIIT or C-MICT. This was followed by 10-months of self-directed training for participants in C-HIIT and C-MICT. Vascular outcomes were evaluated at baseline, 8-weeks, and 12-months.
RESULTS
After 8-weeks, supervised C-HIIT significantly improved relative flow-mediated dilation (FMD) compared with CON (mean difference [MD] 0.8% [0.1, 1.4], p = 0.025). Although not significantly different from CON, the magnitude of change in relative FMD following 8-weeks of supervised C-MICT was similar (MD 0.8% [-0.1, 1.7], p = 0.080). There were no differences in haemodynamic indices, carotid-femoral pulse wave velocity (cfPWV), or aortic reservoir pressure between groups at 8-weeks. After 12-months, there was a significant reduction in haemodynamic indices (time effect, p < 0.05) for both C-HIIT and C-MICT, with no between-group difference. The reduction in cfPWV over 12-months was significantly greater in C-MICT than C-HIIT (group × time effect, p = 0.018). There was no difference in FMD over time or between groups at 12-months.
CONCLUSIONS
Short-term supervised C-HIIT and C-MICT both increased brachial artery FMD compared with CON. Long-term C-HIIT and C-MICT were beneficial for improving haemodynamic indices, but not brachial artery FMD. C-MICT was superior to C-HIIT for improving cfPWV at 12-months.
TRIAL REGISTRATION
Australian New Zealand Clinical Trials Registry Identifier ACTRN12615000475549.
目的
我们比较了低容量联合有氧和抗阻高强度间歇训练（C-HIIT）、联合中等强度持续训练（C-MICT）和候补对照组（CON）在 8 周监督训练后对 2 型糖尿病（T2D）成人血管健康的影响，以及另外 10 个月的自我指导训练。
方法
69 名低活动度的 T2D 成年人被随机分为 8 周的监督 C-HIIT（每周 3 次，每次 78 分钟）、C-MICT（目前的运动指南，每周 4 次，每次 210 分钟）或 CON。CON 在接受 8 周的常规护理后，重新随机分配到 C-HIIT 或 C-MICT。这之后是参与者在 C-HIIT 和 C-MICT 中进行 10 个月的自我指导训练。在基线、8 周和 12 个月时评估血管结果。
结果
8 周后，与 CON 相比，监督 C-HIIT 显著改善了相对血流介导的扩张（FMD）（平均差异 [MD] 0.8% [0.1，1.4]，p=0.025）。尽管与 CON 相比没有显著差异，但 8 周监督 C-MICT 后相对 FMD 的变化幅度相似（MD 0.8% [-0.1，1.7]，p=0.080）。8 周时，各组之间的血流动力学指标、颈动脉-股动脉脉搏波速度（cfPWV）或主动脉储压均无差异。12 个月后，C-HIIT 和 C-MICT 的血流动力学指标均显著降低（时间效应，p<0.05），但组间无差异。与 C-HIIT 相比，12 个月时 C-MICT 引起的 cfPWV 降低更为显著（组间×时间效应，p=0.018）。12 个月时 FMD 无时间变化或组间差异。
结论
短期监督 C-HIIT 和 C-MICT 均使肱动脉 FMD 高于 CON。长期 C-HIIT 和 C-MICT 有益于改善血流动力学指标，但不能改善肱动脉 FMD。与 C-HIIT 相比，C-MICT 在 12 个月时更能改善 cfPWV。
试验注册
澳大利亚和新西兰临床试验注册中心标识符 ACTRN12615000475549。
Zotero 插件