Takimoto Yoichi, Irisawa Atsushi, Hoshi Koki, Yamamiya Akira, Nagashima Kazunori, Minaguchi Takahito, Yamabe Akane, Izawa Naoya, Haruyama Yasuo, Tominaga Keiichi
Department of Gastroenterology, Dokkyo Medical University School of Medicine, Tochigi, Japan.
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.
J Hepatobiliary Pancreat Sci. 2022 Dec;29(12):1274-1282. doi: 10.1002/jhbp.1083. Epub 2021 Dec 7.
BACKGROUND/PURPOSE: The aim of this study is to clarify the relation between the incision size for endoscopic sphincterotomy (EST) and common bile duct stone (CBDS) recurrence.
Patients who underwent elective endoscopic treatment for CBDS between January 2013 and December 2017 were enrolled, excluding those who met the exclusion criteria. The clinical characteristics were investigated using propensity score matching analysis.
A total of 243 patients were investigated. Propensity scores were calculated using multinomial logistic regression with five relevant variables (age, gender, follow-up time, maximum stone size, and bile duct diameter), which led to extraction of 188 cases to compose cohorts of the small and medium EST incision groups. The CBDS recurrence rate was 17.0% in the small incision group and 6.4% in the medium incision group. Multivariate analysis identified the medium incision as an independent predictor of CBDS recurrence (hazard ratio 0.350, 95% confidence interval 0.133-0.922, P = .034). The CBDS non-recurrence rate of the medium incision group was significantly higher than that of the small incision group (log-rank test P = .019).
Our findings suggest that the CBDS recurrence rate was lower in EST with medium incision size than with small incision size.
背景/目的:本研究旨在阐明内镜括约肌切开术(EST)的切口大小与胆总管结石(CBDS)复发之间的关系。
纳入2013年1月至2017年12月期间接受择期内镜治疗CBDS的患者,排除符合排除标准的患者。采用倾向评分匹配分析研究临床特征。
共调查243例患者。使用包含五个相关变量(年龄、性别、随访时间、最大结石大小和胆管直径)的多项逻辑回归计算倾向评分,从而提取188例病例组成EST中小切口组队列。小切口组的CBDS复发率为17.0%,中切口组为6.4%。多变量分析确定中切口是CBDS复发的独立预测因素(风险比0.350,95%置信区间0.133 - 0.922,P = 0.034)。中切口组的CBDS无复发率显著高于小切口组(对数秩检验P = 0.019)。
我们的研究结果表明,EST中切口大小的CBDS复发率低于小切口大小。